Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

Daijuro Hayashi; Yoshiki Hirooka; Hiroki Kawashima; Eizaburo Ohno; Takuya Ishikawa; Takamichi Kuwahara; Manabu Kawai; Takeshi Yamamura; Kazuhiro Furukawa; Kohei Funasaka; Masanao Nakamura; Ryoji Miyahara; Osamu Watanabe; Masatoshi Ishigami; Senju Hashimoto; Hidemi Goto

doi:10.1097/MPA.0000000000001039

Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy.

METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network. Mucosal biopsy was performed before and after spraying to evaluate the incretin response in the jejunal mucosa.

RESULTS: A total of 124 patients participated in the study. There was a positive correlation between villous blood flow change and exocrine pancreas function (R = 0.4337, P < 0.0001). Changes of gastric inhibitory polypeptide and glucagon-like peptide messenger RNAs in biopsy samples were positively correlated with endocrine pancreas function in 88 patients without treatment for diabetes (R = 0.4314, P = 0.0012; R = 0.4112, P = 0.0081). In patients with lower villous blood flow change and decreased pancreatic exocrine function, the prognostic nutritional index were significantly lower (P = 0.0098), compared with other patients.

CONCLUSIONS: This study provides the first evidence of a close functional correlation between the pancreas and the small intestine.

Original language	English
Pages (from-to)	601-608
Number of pages	8
Journal	Pancreas
Volume	47
Issue number	5
DOIs	https://doi.org/10.1097/MPA.0000000000001039
Publication status	Published - 01-05-2018

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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Hayashi, D., Hirooka, Y., Kawashima, H., Ohno, E., Ishikawa, T., Kuwahara, T., Kawai, M., Yamamura, T., Furukawa, K., Funasaka, K., Nakamura, M., Miyahara, R., Watanabe, O., Ishigami, M., Hashimoto, S., & Goto, H. (2018). Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy. Pancreas, 47(5), 601-608. https://doi.org/10.1097/MPA.0000000000001039

Hayashi, Daijuro ; Hirooka, Yoshiki ; Kawashima, Hiroki ; Ohno, Eizaburo ; Ishikawa, Takuya ; Kuwahara, Takamichi ; Kawai, Manabu ; Yamamura, Takeshi ; Furukawa, Kazuhiro ; Funasaka, Kohei ; Nakamura, Masanao ; Miyahara, Ryoji ; Watanabe, Osamu ; Ishigami, Masatoshi ; Hashimoto, Senju ; Goto, Hidemi. / Functional Correlation Between the Pancreas and the Small Intestine in Humans : The First Evaluation Using a Newly Developed Enteroscopy. In: Pancreas. 2018 ; Vol. 47, No. 5. pp. 601-608.

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title = "Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy",

abstract = "OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy.METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network. Mucosal biopsy was performed before and after spraying to evaluate the incretin response in the jejunal mucosa.RESULTS: A total of 124 patients participated in the study. There was a positive correlation between villous blood flow change and exocrine pancreas function (R = 0.4337, P < 0.0001). Changes of gastric inhibitory polypeptide and glucagon-like peptide messenger RNAs in biopsy samples were positively correlated with endocrine pancreas function in 88 patients without treatment for diabetes (R = 0.4314, P = 0.0012; R = 0.4112, P = 0.0081). In patients with lower villous blood flow change and decreased pancreatic exocrine function, the prognostic nutritional index were significantly lower (P = 0.0098), compared with other patients.CONCLUSIONS: This study provides the first evidence of a close functional correlation between the pancreas and the small intestine.",

author = "Daijuro Hayashi and Yoshiki Hirooka and Hiroki Kawashima and Eizaburo Ohno and Takuya Ishikawa and Takamichi Kuwahara and Manabu Kawai and Takeshi Yamamura and Kazuhiro Furukawa and Kohei Funasaka and Masanao Nakamura and Ryoji Miyahara and Osamu Watanabe and Masatoshi Ishigami and Senju Hashimoto and Hidemi Goto",

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Hayashi, D, Hirooka, Y, Kawashima, H, Ohno, E, Ishikawa, T, Kuwahara, T, Kawai, M, Yamamura, T, Furukawa, K, Funasaka, K, Nakamura, M, Miyahara, R, Watanabe, O, Ishigami, M, Hashimoto, S & Goto, H 2018, 'Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy', Pancreas, vol. 47, no. 5, pp. 601-608. https://doi.org/10.1097/MPA.0000000000001039

Functional Correlation Between the Pancreas and the Small Intestine in Humans : The First Evaluation Using a Newly Developed Enteroscopy. / Hayashi, Daijuro; Hirooka, Yoshiki; Kawashima, Hiroki; Ohno, Eizaburo; Ishikawa, Takuya; Kuwahara, Takamichi; Kawai, Manabu; Yamamura, Takeshi; Furukawa, Kazuhiro; Funasaka, Kohei; Nakamura, Masanao; Miyahara, Ryoji; Watanabe, Osamu; Ishigami, Masatoshi; Hashimoto, Senju; Goto, Hidemi.

In: Pancreas, Vol. 47, No. 5, 01.05.2018, p. 601-608.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Functional Correlation Between the Pancreas and the Small Intestine in Humans

T2 - The First Evaluation Using a Newly Developed Enteroscopy

AU - Hayashi, Daijuro

AU - Hirooka, Yoshiki

AU - Kawashima, Hiroki

AU - Ohno, Eizaburo

AU - Ishikawa, Takuya

AU - Kuwahara, Takamichi

AU - Kawai, Manabu

AU - Yamamura, Takeshi

AU - Furukawa, Kazuhiro

AU - Funasaka, Kohei

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Watanabe, Osamu

AU - Ishigami, Masatoshi

AU - Hashimoto, Senju

AU - Goto, Hidemi

PY - 2018/5/1

Y1 - 2018/5/1

N2 - OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy.METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network. Mucosal biopsy was performed before and after spraying to evaluate the incretin response in the jejunal mucosa.RESULTS: A total of 124 patients participated in the study. There was a positive correlation between villous blood flow change and exocrine pancreas function (R = 0.4337, P < 0.0001). Changes of gastric inhibitory polypeptide and glucagon-like peptide messenger RNAs in biopsy samples were positively correlated with endocrine pancreas function in 88 patients without treatment for diabetes (R = 0.4314, P = 0.0012; R = 0.4112, P = 0.0081). In patients with lower villous blood flow change and decreased pancreatic exocrine function, the prognostic nutritional index were significantly lower (P = 0.0098), compared with other patients.CONCLUSIONS: This study provides the first evidence of a close functional correlation between the pancreas and the small intestine.

AB - OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy.METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network. Mucosal biopsy was performed before and after spraying to evaluate the incretin response in the jejunal mucosa.RESULTS: A total of 124 patients participated in the study. There was a positive correlation between villous blood flow change and exocrine pancreas function (R = 0.4337, P < 0.0001). Changes of gastric inhibitory polypeptide and glucagon-like peptide messenger RNAs in biopsy samples were positively correlated with endocrine pancreas function in 88 patients without treatment for diabetes (R = 0.4314, P = 0.0012; R = 0.4112, P = 0.0081). In patients with lower villous blood flow change and decreased pancreatic exocrine function, the prognostic nutritional index were significantly lower (P = 0.0098), compared with other patients.CONCLUSIONS: This study provides the first evidence of a close functional correlation between the pancreas and the small intestine.

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