TY - JOUR
T1 - Functional recovery from chronic writer's cramp by brain-computer interface rehabilitation
T2 - A case report
AU - Hashimoto, Yasunari
AU - Ota, Tetsuo
AU - Mukaino, Masahiko
AU - Liu, Meigen
AU - Ushiba, Junichi
N1 - Publisher Copyright:
© 2014 Hashimoto et al.
PY - 2014
Y1 - 2014
N2 - Background: Dystonia is often currently treated with botulinum toxin injections to spastic muscles, or deep brain stimulation to the basal ganglia. In addition to these pharmacological or neurosurgical measures, a new noninvasive treatment concept, functional modulation using a brain-computer interface, was tested for feasibility. We recorded electroencephalograms (EEGs) over the bilateral sensorimotor cortex from a patient suffering from chronic writer's cramp. The patient was asked to suppress an exaggerated beta frequency component in the EEG during hand extension. Results: The patient completed biweekly one-hour training for 5 months without any adverse effects. Significant decrease of the beta frequency component during handwriting was confirmed, and was associated with clear functional improvement. Conclusion: The current pilot study suggests that a brain-computer Interface can give explicit feedback of ongoing cortical excitability to patients with dystonia and allow them to suppress exaggerated neural activity, resulting in functional recovery.
AB - Background: Dystonia is often currently treated with botulinum toxin injections to spastic muscles, or deep brain stimulation to the basal ganglia. In addition to these pharmacological or neurosurgical measures, a new noninvasive treatment concept, functional modulation using a brain-computer interface, was tested for feasibility. We recorded electroencephalograms (EEGs) over the bilateral sensorimotor cortex from a patient suffering from chronic writer's cramp. The patient was asked to suppress an exaggerated beta frequency component in the EEG during hand extension. Results: The patient completed biweekly one-hour training for 5 months without any adverse effects. Significant decrease of the beta frequency component during handwriting was confirmed, and was associated with clear functional improvement. Conclusion: The current pilot study suggests that a brain-computer Interface can give explicit feedback of ongoing cortical excitability to patients with dystonia and allow them to suppress exaggerated neural activity, resulting in functional recovery.
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U2 - 10.1186/1471-2202-15-103
DO - 10.1186/1471-2202-15-103
M3 - Article
C2 - 25179667
AN - SCOPUS:84989291077
SN - 1471-2202
VL - 15
JO - BMC Neuroscience
JF - BMC Neuroscience
IS - 1
M1 - 103
ER -