Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

Akari Suzuki, Ryo Yamada, Yuta Kochi, Tetsuji Sawada, Yukinori Okada, Koichi Matsuda, Yoichiro Kamatani, Mikako Mori, Kenichi Shimane, Yasuhiko Hirabayashi, Atsushi Takahashi, Tatsuhiko Tsunoda, Akihiko Miyatake, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura, Kazuhiko Yamamoto

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Rheumatoid arthritis is a chronic autoimmune inflammatory disease with a complex genetic etiology. Members of the signaling lymphocyte activation molecule (SLAM) family carry out pivotal functions in innate immunity and in conventional lymphocytes. We identified a linkage disequilibrium block associated with rheumatoid arthritis in the chromosome 1q region containing multiple SLAM family genes. In this block, the association peaked at two functional SNPs (rs3766379 and rs6682654) in CD244 in two independent rheumatoid arthritis cohorts from Japan (P = 3.23 × 10-8 and P = 7.45 × 10-8). We also identified a Japanese cohort with systemic lupus erythematosus that had a similar genotype distribution as the rheumatoid arthritis cohorts. We demonstrated that the rheumatoid arthritis-susceptible alleles of rs3766379 and rs6682654 and their haplotype increased their expression in luciferase and allele-specific transcript quantification assays. CD244 is a genetic risk factor for rheumatoid arthritis and may have a role in the autoimmune process shared by rheumatoid arthritis and systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)1224-1229
Number of pages6
JournalNature Genetics
Volume40
Issue number10
DOIs
Publication statusPublished - 01-10-2008

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Single Nucleotide Polymorphism
Rheumatoid Arthritis
Population
Lymphocyte Activation
Systemic Lupus Erythematosus
Alleles
Linkage Disequilibrium
Luciferases
Innate Immunity
Haplotypes
Autoimmune Diseases
Japan
Chromosomes
Genotype
Lymphocytes
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Suzuki, A., Yamada, R., Kochi, Y., Sawada, T., Okada, Y., Matsuda, K., ... Yamamoto, K. (2008). Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics, 40(10), 1224-1229. https://doi.org/10.1038/ng.205
Suzuki, Akari ; Yamada, Ryo ; Kochi, Yuta ; Sawada, Tetsuji ; Okada, Yukinori ; Matsuda, Koichi ; Kamatani, Yoichiro ; Mori, Mikako ; Shimane, Kenichi ; Hirabayashi, Yasuhiko ; Takahashi, Atsushi ; Tsunoda, Tatsuhiko ; Miyatake, Akihiko ; Kubo, Michiaki ; Kamatani, Naoyuki ; Nakamura, Yusuke ; Yamamoto, Kazuhiko. / Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. In: Nature Genetics. 2008 ; Vol. 40, No. 10. pp. 1224-1229.
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Suzuki, A, Yamada, R, Kochi, Y, Sawada, T, Okada, Y, Matsuda, K, Kamatani, Y, Mori, M, Shimane, K, Hirabayashi, Y, Takahashi, A, Tsunoda, T, Miyatake, A, Kubo, M, Kamatani, N, Nakamura, Y & Yamamoto, K 2008, 'Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population', Nature Genetics, vol. 40, no. 10, pp. 1224-1229. https://doi.org/10.1038/ng.205

Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. / Suzuki, Akari; Yamada, Ryo; Kochi, Yuta; Sawada, Tetsuji; Okada, Yukinori; Matsuda, Koichi; Kamatani, Yoichiro; Mori, Mikako; Shimane, Kenichi; Hirabayashi, Yasuhiko; Takahashi, Atsushi; Tsunoda, Tatsuhiko; Miyatake, Akihiko; Kubo, Michiaki; Kamatani, Naoyuki; Nakamura, Yusuke; Yamamoto, Kazuhiko.

In: Nature Genetics, Vol. 40, No. 10, 01.10.2008, p. 1224-1229.

Research output: Contribution to journalArticle

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T1 - Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

AU - Suzuki, Akari

AU - Yamada, Ryo

AU - Kochi, Yuta

AU - Sawada, Tetsuji

AU - Okada, Yukinori

AU - Matsuda, Koichi

AU - Kamatani, Yoichiro

AU - Mori, Mikako

AU - Shimane, Kenichi

AU - Hirabayashi, Yasuhiko

AU - Takahashi, Atsushi

AU - Tsunoda, Tatsuhiko

AU - Miyatake, Akihiko

AU - Kubo, Michiaki

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

AU - Yamamoto, Kazuhiko

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N2 - Rheumatoid arthritis is a chronic autoimmune inflammatory disease with a complex genetic etiology. Members of the signaling lymphocyte activation molecule (SLAM) family carry out pivotal functions in innate immunity and in conventional lymphocytes. We identified a linkage disequilibrium block associated with rheumatoid arthritis in the chromosome 1q region containing multiple SLAM family genes. In this block, the association peaked at two functional SNPs (rs3766379 and rs6682654) in CD244 in two independent rheumatoid arthritis cohorts from Japan (P = 3.23 × 10-8 and P = 7.45 × 10-8). We also identified a Japanese cohort with systemic lupus erythematosus that had a similar genotype distribution as the rheumatoid arthritis cohorts. We demonstrated that the rheumatoid arthritis-susceptible alleles of rs3766379 and rs6682654 and their haplotype increased their expression in luciferase and allele-specific transcript quantification assays. CD244 is a genetic risk factor for rheumatoid arthritis and may have a role in the autoimmune process shared by rheumatoid arthritis and systemic lupus erythematosus.

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Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K et al. Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics. 2008 Oct 1;40(10):1224-1229. https://doi.org/10.1038/ng.205