Further inflammatory information on metabolic syndrome by adiponectin evaluation

Kunihiro Matsushita, Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Rei Otsuka, Seiko Takefuji, Yo Hotta, Takahisa Kondo, Toyoaki Murohara, Hideaki Toyoshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Despite a close association of adiponectin with metabolic syndrome (MetS), its usefulness as an additional MetS factor has not been well investigated. Methods: We studied 2327 apparently healthy Japanese male office workers aged 35 to 66 years old and investigated cross-sectionally whether categorization by serum adiponectin distinguished participants' levels of high-sensitivity C-reactive protein (CRP) beyond the conventional MetS. Results: In a linear regression analysis, adiponectin was associated with CRP independently of all MetS factors (β = - 0.192, P < 0.001). Furthermore, a graded decrease in CRP level was observed with elevation of adiponectin in every stratum characterized by the presence or absence of each MetS component (trend P < 0.05 in all strata except those of decreased high-density lipoprotein cholesterol or hyperglycemia). Similarly, geometric means of CRP levels (mg/l) decreased as adiponectin increased from the lowest to the highest tertile in all strata classified by the number of MetS components, though a P value did not reach statistical significance in those with 3 MetS components (the stratum of 0 MetS component: 0.41 [95% confidence interval, 0.34-0.49], 0.32 [0.28-0.37] and 0.26 [0.23-0.30], trend P < 0.001; 1 component: 0.45 [0.39-0.52], 0.38 [0.34-0.43], and 0.32 [0.28-0.36], trend P < 0.001; 2 components: 0.58 [0.50-0.67], 0.51 [0.44-0.60], and 0.46 [0.38-0.55], trend P = 0.043; 3 components: 0.80 [0.66-0.96], 0.69 [0.55-0.87], and 0.58 [0.39-0.85], trend P = 0.139). Conclusions: Adiponectin evaluation provides additional inflammatory information on conventional MetS, supporting the potential of hypoadiponectinemia as an additional MetS component for identifying high-risk individuals for cardiovascular disease.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalInternational Journal of Cardiology
Volume124
Issue number3
DOIs
Publication statusPublished - 14-03-2008
Externally publishedYes

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Adiponectin
C-Reactive Protein
Hyperglycemia
HDL Cholesterol
Linear Models
Cardiovascular Diseases
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Matsushita, Kunihiro ; Tamakoshi, Koji ; Yatsuya, Hiroshi ; Wada, Keiko ; Otsuka, Rei ; Takefuji, Seiko ; Hotta, Yo ; Kondo, Takahisa ; Murohara, Toyoaki ; Toyoshima, Hideaki. / Further inflammatory information on metabolic syndrome by adiponectin evaluation. In: International Journal of Cardiology. 2008 ; Vol. 124, No. 3. pp. 339-344.
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title = "Further inflammatory information on metabolic syndrome by adiponectin evaluation",
abstract = "Background: Despite a close association of adiponectin with metabolic syndrome (MetS), its usefulness as an additional MetS factor has not been well investigated. Methods: We studied 2327 apparently healthy Japanese male office workers aged 35 to 66 years old and investigated cross-sectionally whether categorization by serum adiponectin distinguished participants' levels of high-sensitivity C-reactive protein (CRP) beyond the conventional MetS. Results: In a linear regression analysis, adiponectin was associated with CRP independently of all MetS factors (β = - 0.192, P < 0.001). Furthermore, a graded decrease in CRP level was observed with elevation of adiponectin in every stratum characterized by the presence or absence of each MetS component (trend P < 0.05 in all strata except those of decreased high-density lipoprotein cholesterol or hyperglycemia). Similarly, geometric means of CRP levels (mg/l) decreased as adiponectin increased from the lowest to the highest tertile in all strata classified by the number of MetS components, though a P value did not reach statistical significance in those with 3 MetS components (the stratum of 0 MetS component: 0.41 [95{\%} confidence interval, 0.34-0.49], 0.32 [0.28-0.37] and 0.26 [0.23-0.30], trend P < 0.001; 1 component: 0.45 [0.39-0.52], 0.38 [0.34-0.43], and 0.32 [0.28-0.36], trend P < 0.001; 2 components: 0.58 [0.50-0.67], 0.51 [0.44-0.60], and 0.46 [0.38-0.55], trend P = 0.043; 3 components: 0.80 [0.66-0.96], 0.69 [0.55-0.87], and 0.58 [0.39-0.85], trend P = 0.139). Conclusions: Adiponectin evaluation provides additional inflammatory information on conventional MetS, supporting the potential of hypoadiponectinemia as an additional MetS component for identifying high-risk individuals for cardiovascular disease.",
author = "Kunihiro Matsushita and Koji Tamakoshi and Hiroshi Yatsuya and Keiko Wada and Rei Otsuka and Seiko Takefuji and Yo Hotta and Takahisa Kondo and Toyoaki Murohara and Hideaki Toyoshima",
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Matsushita, K, Tamakoshi, K, Yatsuya, H, Wada, K, Otsuka, R, Takefuji, S, Hotta, Y, Kondo, T, Murohara, T & Toyoshima, H 2008, 'Further inflammatory information on metabolic syndrome by adiponectin evaluation', International Journal of Cardiology, vol. 124, no. 3, pp. 339-344. https://doi.org/10.1016/j.ijcard.2007.02.015

Further inflammatory information on metabolic syndrome by adiponectin evaluation. / Matsushita, Kunihiro; Tamakoshi, Koji; Yatsuya, Hiroshi; Wada, Keiko; Otsuka, Rei; Takefuji, Seiko; Hotta, Yo; Kondo, Takahisa; Murohara, Toyoaki; Toyoshima, Hideaki.

In: International Journal of Cardiology, Vol. 124, No. 3, 14.03.2008, p. 339-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Further inflammatory information on metabolic syndrome by adiponectin evaluation

AU - Matsushita, Kunihiro

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Wada, Keiko

AU - Otsuka, Rei

AU - Takefuji, Seiko

AU - Hotta, Yo

AU - Kondo, Takahisa

AU - Murohara, Toyoaki

AU - Toyoshima, Hideaki

PY - 2008/3/14

Y1 - 2008/3/14

N2 - Background: Despite a close association of adiponectin with metabolic syndrome (MetS), its usefulness as an additional MetS factor has not been well investigated. Methods: We studied 2327 apparently healthy Japanese male office workers aged 35 to 66 years old and investigated cross-sectionally whether categorization by serum adiponectin distinguished participants' levels of high-sensitivity C-reactive protein (CRP) beyond the conventional MetS. Results: In a linear regression analysis, adiponectin was associated with CRP independently of all MetS factors (β = - 0.192, P < 0.001). Furthermore, a graded decrease in CRP level was observed with elevation of adiponectin in every stratum characterized by the presence or absence of each MetS component (trend P < 0.05 in all strata except those of decreased high-density lipoprotein cholesterol or hyperglycemia). Similarly, geometric means of CRP levels (mg/l) decreased as adiponectin increased from the lowest to the highest tertile in all strata classified by the number of MetS components, though a P value did not reach statistical significance in those with 3 MetS components (the stratum of 0 MetS component: 0.41 [95% confidence interval, 0.34-0.49], 0.32 [0.28-0.37] and 0.26 [0.23-0.30], trend P < 0.001; 1 component: 0.45 [0.39-0.52], 0.38 [0.34-0.43], and 0.32 [0.28-0.36], trend P < 0.001; 2 components: 0.58 [0.50-0.67], 0.51 [0.44-0.60], and 0.46 [0.38-0.55], trend P = 0.043; 3 components: 0.80 [0.66-0.96], 0.69 [0.55-0.87], and 0.58 [0.39-0.85], trend P = 0.139). Conclusions: Adiponectin evaluation provides additional inflammatory information on conventional MetS, supporting the potential of hypoadiponectinemia as an additional MetS component for identifying high-risk individuals for cardiovascular disease.

AB - Background: Despite a close association of adiponectin with metabolic syndrome (MetS), its usefulness as an additional MetS factor has not been well investigated. Methods: We studied 2327 apparently healthy Japanese male office workers aged 35 to 66 years old and investigated cross-sectionally whether categorization by serum adiponectin distinguished participants' levels of high-sensitivity C-reactive protein (CRP) beyond the conventional MetS. Results: In a linear regression analysis, adiponectin was associated with CRP independently of all MetS factors (β = - 0.192, P < 0.001). Furthermore, a graded decrease in CRP level was observed with elevation of adiponectin in every stratum characterized by the presence or absence of each MetS component (trend P < 0.05 in all strata except those of decreased high-density lipoprotein cholesterol or hyperglycemia). Similarly, geometric means of CRP levels (mg/l) decreased as adiponectin increased from the lowest to the highest tertile in all strata classified by the number of MetS components, though a P value did not reach statistical significance in those with 3 MetS components (the stratum of 0 MetS component: 0.41 [95% confidence interval, 0.34-0.49], 0.32 [0.28-0.37] and 0.26 [0.23-0.30], trend P < 0.001; 1 component: 0.45 [0.39-0.52], 0.38 [0.34-0.43], and 0.32 [0.28-0.36], trend P < 0.001; 2 components: 0.58 [0.50-0.67], 0.51 [0.44-0.60], and 0.46 [0.38-0.55], trend P = 0.043; 3 components: 0.80 [0.66-0.96], 0.69 [0.55-0.87], and 0.58 [0.39-0.85], trend P = 0.139). Conclusions: Adiponectin evaluation provides additional inflammatory information on conventional MetS, supporting the potential of hypoadiponectinemia as an additional MetS component for identifying high-risk individuals for cardiovascular disease.

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