Abstract
Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia- susceptibility genes. Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.
| Original language | English |
|---|---|
| Pages (from-to) | 131-134 |
| Number of pages | 4 |
| Journal | Japanese Journal of Neuropsychopharmacology |
| Volume | 26 |
| Issue number | 3 |
| Publication status | Published - 01-06-2006 |
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All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Psychiatry and Mental health
- Pharmacology, Toxicology and Pharmaceutics(all)
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Future prospect for identification of schizophrenia susceptive genes. / Iwata, Nakao.
In: Japanese Journal of Neuropsychopharmacology, Vol. 26, No. 3, 01.06.2006, p. 131-134.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Future prospect for identification of schizophrenia susceptive genes
AU - Iwata, Nakao
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia- susceptibility genes. Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.
AB - Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia- susceptibility genes. Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.
UR - http://www.scopus.com/inward/record.url?scp=33746253098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746253098&partnerID=8YFLogxK
M3 - Short survey
C2 - 16866214
AN - SCOPUS:33746253098
VL - 26
SP - 131
EP - 134
JO - Japanese Journal of Psychopharmacology
JF - Japanese Journal of Psychopharmacology
SN - 1343-4144
IS - 3
ER -