Future prospect for identification of schizophrenia susceptive genes

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Abstract

Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia- susceptibility genes. Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalJapanese Journal of Neuropsychopharmacology
Volume26
Issue number3
Publication statusPublished - 01-06-2006

Fingerprint

Schizophrenia
Genome
Genetic Linkage
Genome-Wide Association Study
Genetic Polymorphisms
Genes
Single Nucleotide Polymorphism
Research
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Future prospect for identification of schizophrenia susceptive genes",
abstract = "Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia- susceptibility genes. Recently, it has been reported that more than 70{\%} of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.",
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Future prospect for identification of schizophrenia susceptive genes. / Iwata, Nakao.

In: Japanese Journal of Neuropsychopharmacology, Vol. 26, No. 3, 01.06.2006, p. 131-134.

Research output: Contribution to journalShort survey

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