Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA- Receptor function

Tsuyoshi Miyakawa, Takeshi Yagi, Hiromasa Kitazawa, Masahiro Yasuda, Nobufumi Kawai, Kenta Tsuboi, Hiroaki Niki

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Abstract

Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalScience
Volume278
Issue number5338
DOIs
Publication statusPublished - 24-10-1997

All Science Journal Classification (ASJC) codes

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    Miyakawa, T., Yagi, T., Kitazawa, H., Yasuda, M., Kawai, N., Tsuboi, K., & Niki, H. (1997). Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA- Receptor function. Science, 278(5338), 698-701. https://doi.org/10.1126/science.278.5338.698