Fyn-kinase as a determinant of ethanol sensitivity

Relation to NMDA- Receptor function

Tsuyoshi Miyakawa, Takeshi Yagi, Hiromasa Kitazawa, Masahiro Yasuda, Nobufumi Kawai, Kenta Tsuboi, Hiroaki Niki

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalScience
Volume278
Issue number5338
DOIs
Publication statusPublished - 24-10-1997
Externally publishedYes

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N-Methyl-D-Aspartate Receptors
Ethanol
Phosphotransferases
Excitatory Postsynaptic Potentials
Hypnotics and Sedatives
Protein-Tyrosine Kinases
Tyrosine
Hippocampus
Phosphorylation
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Miyakawa, T., Yagi, T., Kitazawa, H., Yasuda, M., Kawai, N., Tsuboi, K., & Niki, H. (1997). Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA- Receptor function. Science, 278(5338), 698-701. https://doi.org/10.1126/science.278.5338.698
Miyakawa, Tsuyoshi ; Yagi, Takeshi ; Kitazawa, Hiromasa ; Yasuda, Masahiro ; Kawai, Nobufumi ; Tsuboi, Kenta ; Niki, Hiroaki. / Fyn-kinase as a determinant of ethanol sensitivity : Relation to NMDA- Receptor function. In: Science. 1997 ; Vol. 278, No. 5338. pp. 698-701.
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Miyakawa, T, Yagi, T, Kitazawa, H, Yasuda, M, Kawai, N, Tsuboi, K & Niki, H 1997, 'Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA- Receptor function', Science, vol. 278, no. 5338, pp. 698-701. https://doi.org/10.1126/science.278.5338.698

Fyn-kinase as a determinant of ethanol sensitivity : Relation to NMDA- Receptor function. / Miyakawa, Tsuyoshi; Yagi, Takeshi; Kitazawa, Hiromasa; Yasuda, Masahiro; Kawai, Nobufumi; Tsuboi, Kenta; Niki, Hiroaki.

In: Science, Vol. 278, No. 5338, 24.10.1997, p. 698-701.

Research output: Contribution to journalArticle

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AU - Miyakawa, Tsuyoshi

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AU - Niki, Hiroaki

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