GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai; Kazuhiro Takuma; Hiroyuki Mizoguchi; Daisuke Ibi; Taku Nagai; Hiroyuki Kamei; Hyoung Chun Kim; Kiyofumi Yamada

doi:10.1016/j.ejphar.2008.10.065

GABA_B receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung Chun Kim, Kiyofumi Yamada

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

In this study, we investigated the effects of GABA_A and GABA_B receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABA_B receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABA_A receptor agonist, had no significant effect. GABA_B receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	European Journal of Pharmacology
Volume	602
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2008.10.065
Publication status	Published - 05-01-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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Arai, S., Takuma, K., Mizoguchi, H., Ibi, D., Nagai, T., Kamei, H., Kim, H. C., & Yamada, K. (2009). GABA_B receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice. European Journal of Pharmacology, 602(1), 101-104. https://doi.org/10.1016/j.ejphar.2008.10.065

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AU - Kamei, Hiroyuki

AU - Kim, Hyoung Chun

AU - Yamada, Kiyofumi

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