GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung Chun Kim, Kiyofumi Yamada

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABAA receptor agonist, had no significant effect. GABAB receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalEuropean Journal of Pharmacology
Volume602
Issue number1
DOIs
Publication statusPublished - 05-01-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

Fingerprint Dive into the research topics of 'GABA<sub>B</sub> receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice'. Together they form a unique fingerprint.

  • Cite this