TY - JOUR
T1 - GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice
AU - Arai, Sawako
AU - Takuma, Kazuhiro
AU - Mizoguchi, Hiroyuki
AU - Ibi, Daisuke
AU - Nagai, Taku
AU - Kamei, Hiroyuki
AU - Kim, Hyoung Chun
AU - Yamada, Kiyofumi
PY - 2009/1/5
Y1 - 2009/1/5
N2 - In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABAA receptor agonist, had no significant effect. GABAB receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.
AB - In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABAA receptor agonist, had no significant effect. GABAB receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.
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U2 - 10.1016/j.ejphar.2008.10.065
DO - 10.1016/j.ejphar.2008.10.065
M3 - Article
C2 - 19028488
AN - SCOPUS:57249108189
VL - 602
SP - 101
EP - 104
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -