Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice

Takenao Koseki, Akihiro Mouri, Shizuka Suzuki, Azusa Nakajima, Takayoshi Mamiya, Yijin Yan, Toshitaka Nabeshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior. Methamphetamine (METH) dependence is becoming a serious problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalAddiction Biology
Volume19
Issue number1
DOIs
Publication statusPublished - 01-01-2014

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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