Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: Analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Akihiko Horiguchi, Shuichi Miyakawa, Shin Ishihara, Masaru Miyazaki, Masayuki Ohtsuka, Hiroaki Shimizu, Keiji Sano, Fumihiko Miura, Tetsuo Ohta, Masato Kayahara, Masato Nagino, Tsuyoshi Igami, Satoshi Hirano, Hiroki Yamaue, Masaji Tani, Masakazu Yamamoto, Takehiro Ota, Mitsuo Shimada, Yuji Morine, Hisafumi KinoshitaMasafumi Yasunaga, Tadahiro Takada

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Purpose: Hepatectomy of segments 4a and 5 (S4a+5) is the recommended treatment for pT2 gallbladder cancer. However, gallbladder bed resection is also occasionally used. Using nationwide data from the Japanese Biliary Tract Cancer Registry and a questionnaire survey, we retrospectively compared these 2 methods of treatment. Method: The study involved 85 patients with pT2, pN0 gallbladder cancer (55 treated with gallbladder bed resection, and 30, with S4a+5 hepatectomy). The prognosis and mode of tumor recurrence following treatment were analyzed retrospectively, with overall survival as the endpoint. Results: The 5-year survival rate did not differ significantly between the 2 groups. Univariate analysis showed that bile duct resection and perineural tumor invasion were significant prognostic factors, but the extent of hepatectomy, location of the major intramural tumor, regional lymph node excision, and histological type were not. Multivariate analysis identified perineural tumor invasion as a significant prognostic factor. Recurrence occurred most frequently in both lobes than S4a+5 of the liver following gallbladder bed resection. Conclusion: In the present study of cases of Japanese Biliary Tract Cancer Registry, it was not possible to conclude that S4a+5 hepatectomy was superior to gallbladder bed resection.

Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume20
Issue number5
DOIs
Publication statusPublished - 06-2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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