TY - JOUR
T1 - Gastric acid reduction leads to an alteration in lower intestinal microflora
AU - Kanno, Takayuki
AU - Matsuki, Takahiro
AU - Oka, Masashi
AU - Utsunomiya, Hirotoshi
AU - Inada, Kenichi
AU - Magari, Hirohito
AU - Inoue, Izumi
AU - Maekita, Takao
AU - Ueda, Kazuki
AU - Enomoto, Shotaro
AU - Iguchi, Mikitaka
AU - Yanaoka, Kimihiko
AU - Tamai, Hideyuki
AU - Akimoto, Shigeru
AU - Nomoto, Koji
AU - Tanaka, Ryuichiro
AU - Ichinose, Masao
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (No. 19590734). The authors express their deepest thanks to Ms. Kazu Konishi for her excellent secretarial assistance.
PY - 2009/4/17
Y1 - 2009/4/17
N2 - To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptomatic human subjects with hypochlorhydria. In both rat and human experiments, most genera or groups of intestinal microflora (facultative and obligate anaerobes) proliferated by gastric acid reduction, and marked and significant increases in the Lactobacilli group and Veillonella, oropharyngeal bacteria, were observed. In rats, potent gastric acid inhibition led to a marked and significant increase of intestinal bacteria, including the Bacteroides fragilis group, while Bifidobacterium, a beneficial bacterial species, remained at a constant level. These results strongly indicate that the gastric acid barrier not only controls the colonization and growth of oropharyngeal bacteria, but also regulates the population and composition of lower intestinal microflora.
AB - To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-time PCR in proton pump inhibitor-treated rats and in asymptomatic human subjects with hypochlorhydria. In both rat and human experiments, most genera or groups of intestinal microflora (facultative and obligate anaerobes) proliferated by gastric acid reduction, and marked and significant increases in the Lactobacilli group and Veillonella, oropharyngeal bacteria, were observed. In rats, potent gastric acid inhibition led to a marked and significant increase of intestinal bacteria, including the Bacteroides fragilis group, while Bifidobacterium, a beneficial bacterial species, remained at a constant level. These results strongly indicate that the gastric acid barrier not only controls the colonization and growth of oropharyngeal bacteria, but also regulates the population and composition of lower intestinal microflora.
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U2 - 10.1016/j.bbrc.2009.02.109
DO - 10.1016/j.bbrc.2009.02.109
M3 - Article
C2 - 19248769
AN - SCOPUS:62649090759
VL - 381
SP - 666
EP - 670
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -