Gastric Lesions in Rats Fed Salted Food Materials Commonly Eaten by Japanese

Iwao Hirono, Masanori Funahashi, Chiyuki Kaneko, Hiroshi Ogino, Mitsuya Ito

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A high intake of salted food is thought to be related to the high incidence of stomach cancer in Japan. In the present study, female F344 rats were divided into four groups. They were fed a nutritionally deficient purified diet (Group 1) and standard purified diet (Group 3) for 113 weeks and the same diets supplemented with salted cuttlefish guts, broiled, salted, dried sardines, pickled radish, and soy sauce (Groups 2 and 4). The incidence of papillomas and ulcers of the forestomach was highest in Group 4, which was given the standard diet supplemented with the salty food materials (p & 0.05). These results suggest the importance of salted food as a suspicious causal factor in human stomach cancer in Japan.

Original languageEnglish
JournalNutrition and Cancer
Issue number2
Publication statusPublished - 01-01-1990

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research


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