Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Tomomitsu Tahara; Sayumi Tahara; Noriyuki Horiguchi; Tomohiko Kawamura; Masaaki Okubo; Mitsuo Nagasaka; Yoshihito Nakagawa; Tomoyuki Shibata; Makoto Urano; Tetsuya Tsukamoto; Makoto Kuroda; Naoki Ohmiya

doi:10.1080/07357907.2019.1663207

Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Urano, Tetsuya Tsukamoto, Makoto Kuroda, Naoki Ohmiya

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

Original language	English
Pages (from-to)	417-426
Number of pages	10
Journal	Cancer Investigation
Volume	37
Issue number	9
DOIs	https://doi.org/10.1080/07357907.2019.1663207
Publication status	Published - 21-10-2019

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/07357907.2019.1663207

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Tahara, T., Tahara, S., Horiguchi, N., Kawamura, T., Okubo, M., Nagasaka, M., Nakagawa, Y., Shibata, T., Urano, M., Tsukamoto, T., Kuroda, M., & Ohmiya, N. (2019). Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. Cancer Investigation, 37(9), 417-426. https://doi.org/10.1080/07357907.2019.1663207

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title = "Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a",

abstract = "To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.",

author = "Tomomitsu Tahara and Sayumi Tahara and Noriyuki Horiguchi and Tomohiko Kawamura and Masaaki Okubo and Mitsuo Nagasaka and Yoshihito Nakagawa and Tomoyuki Shibata and Makoto Urano and Tetsuya Tsukamoto and Makoto Kuroda and Naoki Ohmiya",

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Tahara, T, Tahara, S, Horiguchi, N, Kawamura, T, Okubo, M, Nagasaka, M , Nakagawa, Y , Shibata, T , Urano, M , Tsukamoto, T, Kuroda, M & Ohmiya, N 2019, 'Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a', Cancer Investigation, vol. 37, no. 9, pp. 417-426. https://doi.org/10.1080/07357907.2019.1663207

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AU - Tahara, Tomomitsu

AU - Tahara, Sayumi

AU - Horiguchi, Noriyuki

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Shibata, Tomoyuki

AU - Urano, Makoto

AU - Tsukamoto, Tetsuya

AU - Kuroda, Makoto

AU - Ohmiya, Naoki

PY - 2019/10/21

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AB - To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

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Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Abstract

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