Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a

Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Makoto Urano, Tetsuya Tsukamoto, Makoto Kuroda, Naoki Ohmiya

Research output: Contribution to journalArticle

Abstract

To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. Lower expression of miR-124a correlated with hypermethylation of the miR-124a3 locus. The atrophic type represents gastric microarchitectures associated with irreversibility with H. pylori eradication and downregulation of miR-124a.

Original languageEnglish
Pages (from-to)417-426
Number of pages10
JournalCancer Investigation
Volume37
Issue number9
DOIs
Publication statusPublished - 21-10-2019

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MicroRNAs
Helicobacter pylori
Stomach
Down-Regulation
Narrow Band Imaging
Metaplasia
Gastric Mucosa
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tahara, Tomomitsu ; Tahara, Sayumi ; Horiguchi, Noriyuki ; Kawamura, Tomohiko ; Okubo, Masaaki ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Urano, Makoto ; Tsukamoto, Tetsuya ; Kuroda, Makoto ; Ohmiya, Naoki. / Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. In: Cancer Investigation. 2019 ; Vol. 37, No. 9. pp. 417-426.
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Gastric Mucosal Microarchitectures Associated with Irreversibility with Helicobacter pylori Eradication and Downregulation of Micro RNA (miR)-124a. / Tahara, Tomomitsu; Tahara, Sayumi; Horiguchi, Noriyuki; Kawamura, Tomohiko; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Urano, Makoto; Tsukamoto, Tetsuya; Kuroda, Makoto; Ohmiya, Naoki.

In: Cancer Investigation, Vol. 37, No. 9, 21.10.2019, p. 417-426.

Research output: Contribution to journalArticle

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