Abstract
Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. IL36RN mutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. The association of IL36RN mutation with mucosal involvement in GPP is controversial. We herein report a 60-year-old male GPP patient with no past history of plaque psoriasis presenting with not only severe skin lesions and arthritis but also severe mucosal involvements of pharyngeal and gastrointestinal lesions, which led to gastrointestinal bleeding. Our case did not have any mutation in the IL36RN gene. We should be aware that severe GPP can cause gastrointestinal bleeding. The relevancy of IL36RN mutation with mucosal involvement in GPP remains to be elucidated.
| Original language | English |
|---|---|
| Pages (from-to) | 73-75 |
| Number of pages | 3 |
| Journal | Journal of Dermatology |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-01-2019 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation. / Komatsuda, Shiori; Kamata, Masahiro; Chijiwa, Chika; Namiki, Kaoru; Fukaya, Saki; Hayashi, Kotaro; Fukuyasu, Atsuko; Tanaka, Takamitsu; Ishikawa, Takeko; Ohnishi, Takamitsu; Abe, Koichiro; Yamamoto, Takatsugu; Aozasa, Naohiko; Sugiura, Kazumitsu; Tada, Yayoi.
In: Journal of Dermatology, Vol. 46, No. 1, 01.01.2019, p. 73-75.Research output: Contribution to journal › Article
TY - JOUR
T1 - Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation
AU - Komatsuda, Shiori
AU - Kamata, Masahiro
AU - Chijiwa, Chika
AU - Namiki, Kaoru
AU - Fukaya, Saki
AU - Hayashi, Kotaro
AU - Fukuyasu, Atsuko
AU - Tanaka, Takamitsu
AU - Ishikawa, Takeko
AU - Ohnishi, Takamitsu
AU - Abe, Koichiro
AU - Yamamoto, Takatsugu
AU - Aozasa, Naohiko
AU - Sugiura, Kazumitsu
AU - Tada, Yayoi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. IL36RN mutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. The association of IL36RN mutation with mucosal involvement in GPP is controversial. We herein report a 60-year-old male GPP patient with no past history of plaque psoriasis presenting with not only severe skin lesions and arthritis but also severe mucosal involvements of pharyngeal and gastrointestinal lesions, which led to gastrointestinal bleeding. Our case did not have any mutation in the IL36RN gene. We should be aware that severe GPP can cause gastrointestinal bleeding. The relevancy of IL36RN mutation with mucosal involvement in GPP remains to be elucidated.
AB - Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. IL36RN mutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. The association of IL36RN mutation with mucosal involvement in GPP is controversial. We herein report a 60-year-old male GPP patient with no past history of plaque psoriasis presenting with not only severe skin lesions and arthritis but also severe mucosal involvements of pharyngeal and gastrointestinal lesions, which led to gastrointestinal bleeding. Our case did not have any mutation in the IL36RN gene. We should be aware that severe GPP can cause gastrointestinal bleeding. The relevancy of IL36RN mutation with mucosal involvement in GPP remains to be elucidated.
UR - http://www.scopus.com/inward/record.url?scp=85057222640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057222640&partnerID=8YFLogxK
U2 - 10.1111/1346-8138.14711
DO - 10.1111/1346-8138.14711
M3 - Article
C2 - 30474867
AN - SCOPUS:85057222640
VL - 46
SP - 73
EP - 75
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 1
ER -