GB virus C (GBV-C/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan

Seiji Noguchi; Michio Sata; Hiroshi Suzuki; Kunitaka Fukuizumi; Yohsuke Yamakawa; Miki Shirachi; Tatsunori Nakano; Ken Ichi Ohba; Masashi Mizokami; Kyuichi Tanikawa

doi:10.1016/S0928-4346(97)00032-7

GB virus C (GBV-C/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan

Seiji Noguchi
, Michio Sata
, Hiroshi Suzuki
, Kunitaka Fukuizumi
, Yohsuke Yamakawa
, Miki Shirachi
, Tatsunori Nakano
, Ken Ichi Ohba
, Masashi Mizokami
, Kyuichi Tanikawa

Research output: Contribution to journal › Article › peer-review

Abstract

An epidemiologic study was performed to investigate GBV-C/HGV infection in 460 inhabitants of H town where hepatitis C virus (HCV) is hyper endemic. GBV-C/HGV RNA was detected by reverse transcription hemi-nested polymerase chain reaction (RT-hemi-nested PCR) for the 5' untranslated region (5'-UTR). The nucleotide sequences of GBV-C/HGV 5'-UTR were determined and phylogenetic analysis was performed. GBV-C/HGV RNA, antibody to HCV (anti-HCV), and HCV RNA were detected in 12 (2.6%), 108 (23.5%), and 87 of subjects (18.9%), respectively. The phylogenetic tree analysis indicated that the 12 GBV- C/HGV-positive isolates could be classified as a new GBV-C/HGV group (type 3). No intraspousal transmission of GBV-C/HGV was observed. Four subjects positive for GBV-C/HGV RNA without HCV RNA had normal mean aminotransferase concentration. This study indicated: 1, the prevalence of GBV-C/HGV was lower than that of HCV; 2, Type 3 GBV-C/HGV was the most prevalent; 3. No intraspousal transmission of GBV-C/HGV was observed; and 4, GBV-C/HGV alone may not cause severe liver injury.

Original language	English
Pages (from-to)	149-158
Number of pages	10
Journal	Hepatology Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/S0928-4346(97)00032-7
Publication status	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hepatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0928-4346(97)00032-7

Cite this

@article{01deaa8ed80e4423879a338df2364c5f,

title = "GB virus C (GBV-C/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan",

abstract = "An epidemiologic study was performed to investigate GBV-C/HGV infection in 460 inhabitants of H town where hepatitis C virus (HCV) is hyper endemic. GBV-C/HGV RNA was detected by reverse transcription hemi-nested polymerase chain reaction (RT-hemi-nested PCR) for the 5' untranslated region (5'-UTR). The nucleotide sequences of GBV-C/HGV 5'-UTR were determined and phylogenetic analysis was performed. GBV-C/HGV RNA, antibody to HCV (anti-HCV), and HCV RNA were detected in 12 (2.6\%), 108 (23.5\%), and 87 of subjects (18.9\%), respectively. The phylogenetic tree analysis indicated that the 12 GBV- C/HGV-positive isolates could be classified as a new GBV-C/HGV group (type 3). No intraspousal transmission of GBV-C/HGV was observed. Four subjects positive for GBV-C/HGV RNA without HCV RNA had normal mean aminotransferase concentration. This study indicated: 1, the prevalence of GBV-C/HGV was lower than that of HCV; 2, Type 3 GBV-C/HGV was the most prevalent; 3. No intraspousal transmission of GBV-C/HGV was observed; and 4, GBV-C/HGV alone may not cause severe liver injury.",

keywords = "GB virus C/hepatitis G virus, GBV-C/HGV, HCV, Hepatitis C virus, Hepatitis C virus hyper-endemic area",

author = "Seiji Noguchi and Michio Sata and Hiroshi Suzuki and Kunitaka Fukuizumi and Yohsuke Yamakawa and Miki Shirachi and Tatsunori Nakano and Ohba, \{Ken Ichi\} and Masashi Mizokami and Kyuichi Tanikawa",

year = "1997",

doi = "10.1016/S0928-4346(97)00032-7",

language = "English",

volume = "7",

pages = "149--158",

journal = "Hepatology Research",

issn = "0928-4346",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - GB virus C (GBV-C/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan

AU - Noguchi, Seiji

AU - Sata, Michio

AU - Suzuki, Hiroshi

AU - Fukuizumi, Kunitaka

AU - Yamakawa, Yohsuke

AU - Shirachi, Miki

AU - Nakano, Tatsunori

AU - Ohba, Ken Ichi

AU - Mizokami, Masashi

AU - Tanikawa, Kyuichi

PY - 1997

Y1 - 1997

N2 - An epidemiologic study was performed to investigate GBV-C/HGV infection in 460 inhabitants of H town where hepatitis C virus (HCV) is hyper endemic. GBV-C/HGV RNA was detected by reverse transcription hemi-nested polymerase chain reaction (RT-hemi-nested PCR) for the 5' untranslated region (5'-UTR). The nucleotide sequences of GBV-C/HGV 5'-UTR were determined and phylogenetic analysis was performed. GBV-C/HGV RNA, antibody to HCV (anti-HCV), and HCV RNA were detected in 12 (2.6%), 108 (23.5%), and 87 of subjects (18.9%), respectively. The phylogenetic tree analysis indicated that the 12 GBV- C/HGV-positive isolates could be classified as a new GBV-C/HGV group (type 3). No intraspousal transmission of GBV-C/HGV was observed. Four subjects positive for GBV-C/HGV RNA without HCV RNA had normal mean aminotransferase concentration. This study indicated: 1, the prevalence of GBV-C/HGV was lower than that of HCV; 2, Type 3 GBV-C/HGV was the most prevalent; 3. No intraspousal transmission of GBV-C/HGV was observed; and 4, GBV-C/HGV alone may not cause severe liver injury.

AB - An epidemiologic study was performed to investigate GBV-C/HGV infection in 460 inhabitants of H town where hepatitis C virus (HCV) is hyper endemic. GBV-C/HGV RNA was detected by reverse transcription hemi-nested polymerase chain reaction (RT-hemi-nested PCR) for the 5' untranslated region (5'-UTR). The nucleotide sequences of GBV-C/HGV 5'-UTR were determined and phylogenetic analysis was performed. GBV-C/HGV RNA, antibody to HCV (anti-HCV), and HCV RNA were detected in 12 (2.6%), 108 (23.5%), and 87 of subjects (18.9%), respectively. The phylogenetic tree analysis indicated that the 12 GBV- C/HGV-positive isolates could be classified as a new GBV-C/HGV group (type 3). No intraspousal transmission of GBV-C/HGV was observed. Four subjects positive for GBV-C/HGV RNA without HCV RNA had normal mean aminotransferase concentration. This study indicated: 1, the prevalence of GBV-C/HGV was lower than that of HCV; 2, Type 3 GBV-C/HGV was the most prevalent; 3. No intraspousal transmission of GBV-C/HGV was observed; and 4, GBV-C/HGV alone may not cause severe liver injury.

KW - GB virus C/hepatitis G virus

KW - GBV-C/HGV

KW - HCV

KW - Hepatitis C virus

KW - Hepatitis C virus hyper-endemic area

UR - https://www.scopus.com/pages/publications/12644310319

UR - https://www.scopus.com/pages/publications/12644310319#tab=citedBy

U2 - 10.1016/S0928-4346(97)00032-7

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M3 - Article

AN - SCOPUS:12644310319

SN - 0928-4346

VL - 7

SP - 149

EP - 158

JO - Hepatology Research

JF - Hepatology Research

IS - 3

ER -

GB virus C (GBV-C/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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