GB virus C/hepatitis G virus infection in southern China

Rong Rong Wu, Masashi Mizokami, Kun Cao, Tatsunori Nakano, Xian Min Ge, Su Seng Wang, Etsuro Orito, Ken Ichi Ohba, Motokazu Mukaide, Kazumasa Hikiji, Johnson Y.N. Lau, Shiro Iino

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69 Citations (Scopus)


The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVDUs, 20 of 80 persons with liver disease, and 1 of 50 blood donors. Among IVDUs, GBV- C/HGV infection was associated with antibodies to hepatitis C virus (HCV) and with hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined and analyzed by molecular evolutionary analysis. In a phylogenetic tree, the isolates were grouped in three clusters with GBV-C and HGV grouped in two clusters. These data indicate that GBV-C/HGV infection is common in China among IVDUs but uncommon among persons with liver disease without HBsAg or anti-HCV and that there is a new group of GBV-C/HGV.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalJournal of Infectious Diseases
Issue number1
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases


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