TY - JOUR
T1 - GB virus C/hepatitis G virus infection in southern China
AU - Wu, Rong Rong
AU - Mizokami, Masashi
AU - Cao, Kun
AU - Nakano, Tatsunori
AU - Ge, Xian Min
AU - Wang, Su Seng
AU - Orito, Etsuro
AU - Ohba, Ken Ichi
AU - Mukaide, Motokazu
AU - Hikiji, Kazumasa
AU - Lau, Johnson Y.N.
AU - Iino, Shiro
PY - 1997
Y1 - 1997
N2 - The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVDUs, 20 of 80 persons with liver disease, and 1 of 50 blood donors. Among IVDUs, GBV- C/HGV infection was associated with antibodies to hepatitis C virus (HCV) and with hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined and analyzed by molecular evolutionary analysis. In a phylogenetic tree, the isolates were grouped in three clusters with GBV-C and HGV grouped in two clusters. These data indicate that GBV-C/HGV infection is common in China among IVDUs but uncommon among persons with liver disease without HBsAg or anti-HCV and that there is a new group of GBV-C/HGV.
AB - The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVDUs, 20 of 80 persons with liver disease, and 1 of 50 blood donors. Among IVDUs, GBV- C/HGV infection was associated with antibodies to hepatitis C virus (HCV) and with hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined and analyzed by molecular evolutionary analysis. In a phylogenetic tree, the isolates were grouped in three clusters with GBV-C and HGV grouped in two clusters. These data indicate that GBV-C/HGV infection is common in China among IVDUs but uncommon among persons with liver disease without HBsAg or anti-HCV and that there is a new group of GBV-C/HGV.
UR - http://www.scopus.com/inward/record.url?scp=16944364987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16944364987&partnerID=8YFLogxK
U2 - 10.1093/infdis/175.1.168
DO - 10.1093/infdis/175.1.168
M3 - Article
C2 - 8985213
AN - SCOPUS:16944364987
SN - 0022-1899
VL - 175
SP - 168
EP - 171
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -