TY - JOUR
T1 - GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals
T2 - Data from the J-MICC Study
AU - Hishida, Asahi
AU - Takashima, Naoyuki
AU - Turin, Tanvir Chowdhury
AU - Kawai, Sayo
AU - Wakai, Kenji
AU - Hamajima, Nobuyuki
AU - Hosono, Satoyo
AU - Nishida, Yuichiro
AU - Suzuki, Sadao
AU - Nakahata, Noriko
AU - Mikami, Haruo
AU - Ohnaka, Keizo
AU - Matsui, Daisuke
AU - Katsuura-Kamano, Sakurako
AU - Kubo, Michiaki
AU - Tanaka, Hideo
AU - Kita, Yoshikuni
N1 - Funding Information:
Financial support This study was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas of Cancer (No. 17015018) and Scientific Support Programs for Cancer Research, Grant-in-Aid for Scientific Research on Innovative Areas (No. 221S0001) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.
PY - 2014/4
Y1 - 2014/4
N2 - Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
AB - Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
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U2 - 10.1007/s40620-013-0025-0
DO - 10.1007/s40620-013-0025-0
M3 - Article
C2 - 24535998
AN - SCOPUS:84901033768
SN - 1121-8428
VL - 27
SP - 143
EP - 149
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 2
ER -
