GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals

Data from the J-MICC Study

Asahi Hishida, Naoyuki Takashima, Tanvir Chowdhury Turin, Sayo Kawai, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Yuichiro Nishida, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Daisuke Matsui, Sakurako Katsuura-Kamano, Michiaki Kubo, Hideo Tanaka, Yoshikuni Kita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalJournal of Nephrology
Volume27
Issue number2
DOIs
Publication statusPublished - 01-01-2014

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Chronic Renal Insufficiency
Genotype
Japan
Smoking
Odds Ratio
Glucokinase
Gene-Environment Interaction
glucokinase regulatory protein
Glomerular Filtration Rate
Chronic Kidney Failure
Linear Models
Cohort Studies
Cardiovascular Diseases
Logistic Models

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Hishida, A., Takashima, N., Turin, T. C., Kawai, S., Wakai, K., Hamajima, N., ... Kita, Y. (2014). GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: Data from the J-MICC Study. Journal of Nephrology, 27(2), 143-149. https://doi.org/10.1007/s40620-013-0025-0
Hishida, Asahi ; Takashima, Naoyuki ; Turin, Tanvir Chowdhury ; Kawai, Sayo ; Wakai, Kenji ; Hamajima, Nobuyuki ; Hosono, Satoyo ; Nishida, Yuichiro ; Suzuki, Sadao ; Nakahata, Noriko ; Mikami, Haruo ; Ohnaka, Keizo ; Matsui, Daisuke ; Katsuura-Kamano, Sakurako ; Kubo, Michiaki ; Tanaka, Hideo ; Kita, Yoshikuni. / GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals : Data from the J-MICC Study. In: Journal of Nephrology. 2014 ; Vol. 27, No. 2. pp. 143-149.
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title = "GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: Data from the J-MICC Study",
abstract = "Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.",
author = "Asahi Hishida and Naoyuki Takashima and Turin, {Tanvir Chowdhury} and Sayo Kawai and Kenji Wakai and Nobuyuki Hamajima and Satoyo Hosono and Yuichiro Nishida and Sadao Suzuki and Noriko Nakahata and Haruo Mikami and Keizo Ohnaka and Daisuke Matsui and Sakurako Katsuura-Kamano and Michiaki Kubo and Hideo Tanaka and Yoshikuni Kita",
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Hishida, A, Takashima, N, Turin, TC, Kawai, S, Wakai, K, Hamajima, N, Hosono, S, Nishida, Y, Suzuki, S, Nakahata, N, Mikami, H, Ohnaka, K, Matsui, D, Katsuura-Kamano, S, Kubo, M, Tanaka, H & Kita, Y 2014, 'GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: Data from the J-MICC Study', Journal of Nephrology, vol. 27, no. 2, pp. 143-149. https://doi.org/10.1007/s40620-013-0025-0

GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals : Data from the J-MICC Study. / Hishida, Asahi; Takashima, Naoyuki; Turin, Tanvir Chowdhury; Kawai, Sayo; Wakai, Kenji; Hamajima, Nobuyuki; Hosono, Satoyo; Nishida, Yuichiro; Suzuki, Sadao; Nakahata, Noriko; Mikami, Haruo; Ohnaka, Keizo; Matsui, Daisuke; Katsuura-Kamano, Sakurako; Kubo, Michiaki; Tanaka, Hideo; Kita, Yoshikuni.

In: Journal of Nephrology, Vol. 27, No. 2, 01.01.2014, p. 143-149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals

T2 - Data from the J-MICC Study

AU - Hishida, Asahi

AU - Takashima, Naoyuki

AU - Turin, Tanvir Chowdhury

AU - Kawai, Sayo

AU - Wakai, Kenji

AU - Hamajima, Nobuyuki

AU - Hosono, Satoyo

AU - Nishida, Yuichiro

AU - Suzuki, Sadao

AU - Nakahata, Noriko

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Matsui, Daisuke

AU - Katsuura-Kamano, Sakurako

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Kita, Yoshikuni

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

AB - Background: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. Methods: The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi- Institutional Collaborative Cohort Study. Age- and sexadjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. Results: When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. Conclusion: The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

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U2 - 10.1007/s40620-013-0025-0

DO - 10.1007/s40620-013-0025-0

M3 - Article

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SP - 143

EP - 149

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 2

ER -