Generalized allergic reaction in response to exercise due to strawberry gibberellin-regulated protein: a case report

Chisato Inuo, Fumiko Okazaki, Rie Shiraki, Yutaka Tanaka, Keiko Momma, Yasuto Kondo, Hiroshi Narita

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background: The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have been reported to include Bet v 1 and profilin, which mainly cause oral symptoms, and lipid transfer protein (LTP). Recently, gibberellin-regulated protein (GRP) has been identified as an allergen that induces generalized symptoms in peach-, orange-, and plum-related allergies. Most patients with food allergies induced by GRP show allergic symptoms accompanied by cofactors, such as exercise or drugs. To date, there are very few reports of generalized symptoms induced by strawberry. Case presentation: We evaluated the reactivity of strawberry GRP in a 15-year-old boy who was confirmed to have generalized symptoms induced by strawberry with exercise using an oral food challenge test (OFCT). The patient’s serum exhibited a strong positive reaction to strawberry GRP but not to peach GRP or peach LTP. The patient’s basophils reacted to strawberry and peach GRP but not to peach LTP. Conclusions: Strawberry GRP may be a causative component for strawberry with exercise-induced generalized symptoms in this patient. This is the first study to investigate the role of GRP in strawberry with cofactor-induced allergic symptoms. Further epidemiological and clinical researches are necessary to improve diagnostic and therapeutic approaches for patients with strawberry allergy.

Original languageEnglish
Article number49
JournalAllergy, Asthma and Clinical Immunology
Issue number1
Publication statusPublished - 12-2022

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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