Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA

Yusuke Masano; Chika Saegusa; Mitsuru Ishikawa; Tatsuo Matsunaga; Hideyuki Okano; Masato Fujioka

doi:10.1016/j.scr.2024.103452

Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA

Yusuke Masano, Chika Saegusa, Mitsuru Ishikawa, Tatsuo Matsunaga, Hideyuki Okano, Masato Fujioka

International Center for Brain Science

Research output: Contribution to journal › Article › peer-review

Abstract

We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.

Original language	English
Article number	103452
Journal	Stem Cell Research
Volume	78
DOIs	https://doi.org/10.1016/j.scr.2024.103452
Publication status	Published - 08-2024

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

Access to Document

10.1016/j.scr.2024.103452

Cite this

@article{06f4bebfdfbd496888870671c9f30be5,

title = "Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA",

abstract = "We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.",

author = "Yusuke Masano and Chika Saegusa and Mitsuru Ishikawa and Tatsuo Matsunaga and Hideyuki Okano and Masato Fujioka",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = aug,

doi = "10.1016/j.scr.2024.103452",

language = "English",

volume = "78",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA

AU - Masano, Yusuke

AU - Saegusa, Chika

AU - Ishikawa, Mitsuru

AU - Matsunaga, Tatsuo

AU - Okano, Hideyuki

AU - Fujioka, Masato

PY - 2024/8

Y1 - 2024/8

N2 - We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.

AB - We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.

UR - http://www.scopus.com/inward/record.url?scp=85194384915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85194384915&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2024.103452

DO - 10.1016/j.scr.2024.103452

M3 - Article

C2 - 38815527

AN - SCOPUS:85194384915

SN - 1873-5061

VL - 78

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 103452

ER -

Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this