Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family

Satoru Yoshida; Hanayuki Okura; Hidetaka Suga; Mika Soen; Yohei Kawaguchi; Junki Kurimoto; Takashi Miyata; Hiroshi Takagi; Hiroshi Arima; Tatsuya Fujikawa; Fumio Otsuka; Akifumi Matsuyama

doi:10.1016/j.scr.2020.101960

Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family

Satoru Yoshida, Hanayuki Okura, Hidetaka Suga, Mika Soen, Yohei Kawaguchi, Junki Kurimoto, Takashi Miyata, Hiroshi Takagi, Hiroshi Arima, Tatsuya Fujikawa, Fumio Otsuka, Akifumi Matsuyama

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Abstract

Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived from peripheral blood mononuclear cells of two affected individuals in a family affected by familial neurohypophyseal diabetes insipidus carrying the c.314G>C mutation. The expression of pluripotency markers (NANOG, OCT4, and SOX2), maintenance of a normal karyotype, absence of episomal vectors used for iPSC generation, and presence of the original pathogenic mutation were confirmed for each iPSC line. The ability to differentiate into three germ layers was confirmed by a teratoma formation assay. These iPSC lines can help in disease recapitulation in vitro using organoids and elucidation of disease mechanisms.

Original language	English
Article number	101960
Journal	Stem Cell Research
Volume	48
DOIs	https://doi.org/10.1016/j.scr.2020.101960
Publication status	Published - 10-2020

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scr.2020.101960

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Yoshida, S., Okura, H., Suga, H., Soen, M., Kawaguchi, Y., Kurimoto, J., Miyata, T., Takagi, H., Arima, H., Fujikawa, T., Otsuka, F., & Matsuyama, A. (2020). Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family. Stem Cell Research, 48, Article 101960. https://doi.org/10.1016/j.scr.2020.101960

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title = "Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family",

abstract = "Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived from peripheral blood mononuclear cells of two affected individuals in a family affected by familial neurohypophyseal diabetes insipidus carrying the c.314G>C mutation. The expression of pluripotency markers (NANOG, OCT4, and SOX2), maintenance of a normal karyotype, absence of episomal vectors used for iPSC generation, and presence of the original pathogenic mutation were confirmed for each iPSC line. The ability to differentiate into three germ layers was confirmed by a teratoma formation assay. These iPSC lines can help in disease recapitulation in vitro using organoids and elucidation of disease mechanisms.",

author = "Satoru Yoshida and Hanayuki Okura and Hidetaka Suga and Mika Soen and Yohei Kawaguchi and Junki Kurimoto and Takashi Miyata and Hiroshi Takagi and Hiroshi Arima and Tatsuya Fujikawa and Fumio Otsuka and Akifumi Matsuyama",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = oct,

doi = "10.1016/j.scr.2020.101960",

language = "English",

volume = "48",

journal = "Stem Cell Research",

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Yoshida, S, Okura, H, Suga, H, Soen, M, Kawaguchi, Y, Kurimoto, J, Miyata, T, Takagi, H, Arima, H, Fujikawa, T, Otsuka, F & Matsuyama, A 2020, 'Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family', Stem Cell Research, vol. 48, 101960. https://doi.org/10.1016/j.scr.2020.101960

TY - JOUR

T1 - Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family

AU - Yoshida, Satoru

AU - Okura, Hanayuki

AU - Suga, Hidetaka

AU - Soen, Mika

AU - Kawaguchi, Yohei

AU - Kurimoto, Junki

AU - Miyata, Takashi

AU - Takagi, Hiroshi

AU - Arima, Hiroshi

AU - Fujikawa, Tatsuya

AU - Otsuka, Fumio

AU - Matsuyama, Akifumi

PY - 2020/10

Y1 - 2020/10

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AB - Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived from peripheral blood mononuclear cells of two affected individuals in a family affected by familial neurohypophyseal diabetes insipidus carrying the c.314G>C mutation. The expression of pluripotency markers (NANOG, OCT4, and SOX2), maintenance of a normal karyotype, absence of episomal vectors used for iPSC generation, and presence of the original pathogenic mutation were confirmed for each iPSC line. The ability to differentiate into three germ layers was confirmed by a teratoma formation assay. These iPSC lines can help in disease recapitulation in vitro using organoids and elucidation of disease mechanisms.

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Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family

Abstract

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