Genetic aberrations in gliomatosis cerebri

Marcus L. Ware, Yuichi Hirose, Bernd W. Scheithauer, Ru Fang Yeh, Mary C. Mayo, Justin S. Smith, Susan Chang, Soonmee Cha, Tarik Tihan, Burt G. Feuerstein

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

OBJECTIVE: Identifying the genetic alterations in gliomatosis cerebri (GC) may yield clinically useful prognostic markers and provide clues as to whether GC represents a distinct pathological entity or is an extreme form of diffusely infiltrative glioma. METHODS: Clinical histories, treatment histories, magnetic resonance imaging, and pathological analysis of patients with GC treated at either the University of California San Francisco or the Mayo Clinic were reviewed. Degenerate oligonucleotide-primed polymerase chain reaction was performed on biopsy samples of GC. Comparative genomic hybridization was used to determine relative deoxyribonucleic acid copy number. We evaluated relationships of clinical and radiological treatment and comparative genomic hybridization data to survival after diagnosis with Cox regression analysis. RESULTS: Radiographic analysis and biopsy specimens were available for study in 29 patients (17 men, 12 women). Comparative genomic hybridization was successfully performed in 22 patients. Contrast enhancement was the most significant predictor of poor survival (P = 0.0026). Loss of chromosomes 13q and 10q and gains of 7q were also independent significant predictors of poor survival (P = 0.0032, 0.0335, and 0.0487, respectively). Patients treated with temozolomide or with radiation therapy had improved survival, but this effect did not reach statistical significance (P = 0.180 and 0.124, respectively). CONCLUSION: Chromosomal aberrations associated with aggressive astrocytomas are predictors of poor outcome in patients with GC. This suggests that GC may be an architectural variant of diffuse astrocytomas. The presence of these aberrations and the presence of any contrast enhancement on magnetic resonance imaging scans are possible stratifiers for patients with GC. Stratification of GC into higher- and lower-grade forms may be useful in tailoring treatments to patients with this disease.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalNeurosurgery
Volume60
Issue number1
DOIs
Publication statusPublished - 01-01-2007
Externally publishedYes

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Neuroepithelial Neoplasms
Comparative Genomic Hybridization
Survival
temozolomide
Astrocytoma
Magnetic Resonance Imaging
Biopsy
San Francisco
Glioma
Chromosome Aberrations
Radiotherapy
Therapeutics
Chromosomes
Regression Analysis
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Surgery

Cite this

Ware, M. L., Hirose, Y., Scheithauer, B. W., Yeh, R. F., Mayo, M. C., Smith, J. S., ... Feuerstein, B. G. (2007). Genetic aberrations in gliomatosis cerebri. Neurosurgery, 60(1), 150-158. https://doi.org/10.1227/01.NEU.0000249203.73849.5D
Ware, Marcus L. ; Hirose, Yuichi ; Scheithauer, Bernd W. ; Yeh, Ru Fang ; Mayo, Mary C. ; Smith, Justin S. ; Chang, Susan ; Cha, Soonmee ; Tihan, Tarik ; Feuerstein, Burt G. / Genetic aberrations in gliomatosis cerebri. In: Neurosurgery. 2007 ; Vol. 60, No. 1. pp. 150-158.
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abstract = "OBJECTIVE: Identifying the genetic alterations in gliomatosis cerebri (GC) may yield clinically useful prognostic markers and provide clues as to whether GC represents a distinct pathological entity or is an extreme form of diffusely infiltrative glioma. METHODS: Clinical histories, treatment histories, magnetic resonance imaging, and pathological analysis of patients with GC treated at either the University of California San Francisco or the Mayo Clinic were reviewed. Degenerate oligonucleotide-primed polymerase chain reaction was performed on biopsy samples of GC. Comparative genomic hybridization was used to determine relative deoxyribonucleic acid copy number. We evaluated relationships of clinical and radiological treatment and comparative genomic hybridization data to survival after diagnosis with Cox regression analysis. RESULTS: Radiographic analysis and biopsy specimens were available for study in 29 patients (17 men, 12 women). Comparative genomic hybridization was successfully performed in 22 patients. Contrast enhancement was the most significant predictor of poor survival (P = 0.0026). Loss of chromosomes 13q and 10q and gains of 7q were also independent significant predictors of poor survival (P = 0.0032, 0.0335, and 0.0487, respectively). Patients treated with temozolomide or with radiation therapy had improved survival, but this effect did not reach statistical significance (P = 0.180 and 0.124, respectively). CONCLUSION: Chromosomal aberrations associated with aggressive astrocytomas are predictors of poor outcome in patients with GC. This suggests that GC may be an architectural variant of diffuse astrocytomas. The presence of these aberrations and the presence of any contrast enhancement on magnetic resonance imaging scans are possible stratifiers for patients with GC. Stratification of GC into higher- and lower-grade forms may be useful in tailoring treatments to patients with this disease.",
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Ware, ML, Hirose, Y, Scheithauer, BW, Yeh, RF, Mayo, MC, Smith, JS, Chang, S, Cha, S, Tihan, T & Feuerstein, BG 2007, 'Genetic aberrations in gliomatosis cerebri', Neurosurgery, vol. 60, no. 1, pp. 150-158. https://doi.org/10.1227/01.NEU.0000249203.73849.5D

Genetic aberrations in gliomatosis cerebri. / Ware, Marcus L.; Hirose, Yuichi; Scheithauer, Bernd W.; Yeh, Ru Fang; Mayo, Mary C.; Smith, Justin S.; Chang, Susan; Cha, Soonmee; Tihan, Tarik; Feuerstein, Burt G.

In: Neurosurgery, Vol. 60, No. 1, 01.01.2007, p. 150-158.

Research output: Contribution to journalReview article

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T1 - Genetic aberrations in gliomatosis cerebri

AU - Ware, Marcus L.

AU - Hirose, Yuichi

AU - Scheithauer, Bernd W.

AU - Yeh, Ru Fang

AU - Mayo, Mary C.

AU - Smith, Justin S.

AU - Chang, Susan

AU - Cha, Soonmee

AU - Tihan, Tarik

AU - Feuerstein, Burt G.

PY - 2007/1/1

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N2 - OBJECTIVE: Identifying the genetic alterations in gliomatosis cerebri (GC) may yield clinically useful prognostic markers and provide clues as to whether GC represents a distinct pathological entity or is an extreme form of diffusely infiltrative glioma. METHODS: Clinical histories, treatment histories, magnetic resonance imaging, and pathological analysis of patients with GC treated at either the University of California San Francisco or the Mayo Clinic were reviewed. Degenerate oligonucleotide-primed polymerase chain reaction was performed on biopsy samples of GC. Comparative genomic hybridization was used to determine relative deoxyribonucleic acid copy number. We evaluated relationships of clinical and radiological treatment and comparative genomic hybridization data to survival after diagnosis with Cox regression analysis. RESULTS: Radiographic analysis and biopsy specimens were available for study in 29 patients (17 men, 12 women). Comparative genomic hybridization was successfully performed in 22 patients. Contrast enhancement was the most significant predictor of poor survival (P = 0.0026). Loss of chromosomes 13q and 10q and gains of 7q were also independent significant predictors of poor survival (P = 0.0032, 0.0335, and 0.0487, respectively). Patients treated with temozolomide or with radiation therapy had improved survival, but this effect did not reach statistical significance (P = 0.180 and 0.124, respectively). CONCLUSION: Chromosomal aberrations associated with aggressive astrocytomas are predictors of poor outcome in patients with GC. This suggests that GC may be an architectural variant of diffuse astrocytomas. The presence of these aberrations and the presence of any contrast enhancement on magnetic resonance imaging scans are possible stratifiers for patients with GC. Stratification of GC into higher- and lower-grade forms may be useful in tailoring treatments to patients with this disease.

AB - OBJECTIVE: Identifying the genetic alterations in gliomatosis cerebri (GC) may yield clinically useful prognostic markers and provide clues as to whether GC represents a distinct pathological entity or is an extreme form of diffusely infiltrative glioma. METHODS: Clinical histories, treatment histories, magnetic resonance imaging, and pathological analysis of patients with GC treated at either the University of California San Francisco or the Mayo Clinic were reviewed. Degenerate oligonucleotide-primed polymerase chain reaction was performed on biopsy samples of GC. Comparative genomic hybridization was used to determine relative deoxyribonucleic acid copy number. We evaluated relationships of clinical and radiological treatment and comparative genomic hybridization data to survival after diagnosis with Cox regression analysis. RESULTS: Radiographic analysis and biopsy specimens were available for study in 29 patients (17 men, 12 women). Comparative genomic hybridization was successfully performed in 22 patients. Contrast enhancement was the most significant predictor of poor survival (P = 0.0026). Loss of chromosomes 13q and 10q and gains of 7q were also independent significant predictors of poor survival (P = 0.0032, 0.0335, and 0.0487, respectively). Patients treated with temozolomide or with radiation therapy had improved survival, but this effect did not reach statistical significance (P = 0.180 and 0.124, respectively). CONCLUSION: Chromosomal aberrations associated with aggressive astrocytomas are predictors of poor outcome in patients with GC. This suggests that GC may be an architectural variant of diffuse astrocytomas. The presence of these aberrations and the presence of any contrast enhancement on magnetic resonance imaging scans are possible stratifiers for patients with GC. Stratification of GC into higher- and lower-grade forms may be useful in tailoring treatments to patients with this disease.

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Ware ML, Hirose Y, Scheithauer BW, Yeh RF, Mayo MC, Smith JS et al. Genetic aberrations in gliomatosis cerebri. Neurosurgery. 2007 Jan 1;60(1):150-158. https://doi.org/10.1227/01.NEU.0000249203.73849.5D