TY - JOUR
T1 - Genetic animal models of schizophrenia related with the hypothesis of abnormal neurodevelopment
AU - Lu, Lingling
AU - Mamiya, Takayoshi
AU - Koseki, Takenao
AU - Mouri, Akihiro
AU - Nabeshima, Toshitaka
PY - 2011/9
Y1 - 2011/9
N2 - Accumulating evidence supports the existence of an overlap in genetic susceptibility with schizophrenia. Translation of human genetic mutations into animals is one of the most important strategies to study the pathogenesis of schizophrenia, identify potential drug targets, and test new medicines for antipsychotic treatment. Recent discoveries of susceptibility genes for schizophrenia make the possibility to develop newer genetic mouse models based on the neurodevelopmental hypotheses of schizophrenia. Although it is not possible to mimic all schizophrenic symptoms by these animal models, the genetic mouse models based on the neurodevelopmental hypothesis are widely developed to reproduce several schizophrenia-like behavioral and biochemical changes in humans. In this mini review, we will discuss the neuropathological and behavioral manifestations of representative genetic mouse models for schizophrenia, associated with the hypothesis of abnormal neurodevelopment.
AB - Accumulating evidence supports the existence of an overlap in genetic susceptibility with schizophrenia. Translation of human genetic mutations into animals is one of the most important strategies to study the pathogenesis of schizophrenia, identify potential drug targets, and test new medicines for antipsychotic treatment. Recent discoveries of susceptibility genes for schizophrenia make the possibility to develop newer genetic mouse models based on the neurodevelopmental hypotheses of schizophrenia. Although it is not possible to mimic all schizophrenic symptoms by these animal models, the genetic mouse models based on the neurodevelopmental hypothesis are widely developed to reproduce several schizophrenia-like behavioral and biochemical changes in humans. In this mini review, we will discuss the neuropathological and behavioral manifestations of representative genetic mouse models for schizophrenia, associated with the hypothesis of abnormal neurodevelopment.
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U2 - 10.1248/bpb.34.1358
DO - 10.1248/bpb.34.1358
M3 - Review article
C2 - 21881217
AN - SCOPUS:80052501979
SN - 0918-6158
VL - 34
SP - 1358
EP - 1363
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 9
ER -
