Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese

Takenori Okumura, Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Tomoko Tsunoka, Yasuhisa Fukuo, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

Fingerprint

Methamphetamine
Psychotic Disorders
Nitric Oxide
Schizophrenia
Ethics Committees
Nitric Oxide Synthase Type I
School Health Services
Second Messenger Systems
N-Methyl-D-Aspartate Receptors
Informed Consent
Haplotypes
Genes
Substance-Related Disorders
Single Nucleotide Polymorphism
Neurotransmitter Agents
Case-Control Studies
Alleles
Genotype
Medicine
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Okumura, Takenori ; Okochi, Tomo ; Kishi, Taro ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Tsunoka, Tomoko ; Fukuo, Yasuhisa ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Ujike, Hiroshi ; Iwata, Nakao. / Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 155-159.
@article{363f9cfe4b0d4657bd863ea6e9063443,
title = "Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese",
abstract = "The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.",
author = "Takenori Okumura and Tomo Okochi and Taro Kishi and Masashi Ikeda and Tsuyoshi Kitajima and Yoko Kinoshita and Kunihiro Kawashima and Tomoko Tsunoka and Yasuhisa Fukuo and Toshiya Inada and Mitsuhiko Yamada and Naohisa Uchimura and Masaomi Iyo and Ichiro Sora and Norio Ozaki and Hiroshi Ujike and Nakao Iwata",
year = "2011",
month = "3",
day = "30",
doi = "10.2174/157015911795017308",
language = "English",
volume = "9",
pages = "155--159",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

Okumura, T, Okochi, T, Kishi, T, Ikeda, M, Kitajima, T, Kinoshita, Y, Kawashima, K, Tsunoka, T, Fukuo, Y, Inada, T, Yamada, M, Uchimura, N, Iyo, M, Sora, I, Ozaki, N, Ujike, H & Iwata, N 2011, 'Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese', Current Neuropharmacology, vol. 9, no. 1, pp. 155-159. https://doi.org/10.2174/157015911795017308

Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese. / Okumura, Takenori; Okochi, Tomo; Kishi, Taro; Ikeda, Masashi; Kitajima, Tsuyoshi; Kinoshita, Yoko; Kawashima, Kunihiro; Tsunoka, Tomoko; Fukuo, Yasuhisa; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Ujike, Hiroshi; Iwata, Nakao.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 155-159.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese

AU - Okumura, Takenori

AU - Okochi, Tomo

AU - Kishi, Taro

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Tsunoka, Tomoko

AU - Fukuo, Yasuhisa

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Ujike, Hiroshi

AU - Iwata, Nakao

PY - 2011/3/30

Y1 - 2011/3/30

N2 - The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

AB - The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=79953054583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953054583&partnerID=8YFLogxK

U2 - 10.2174/157015911795017308

DO - 10.2174/157015911795017308

M3 - Article

C2 - 21886582

AN - SCOPUS:79953054583

VL - 9

SP - 155

EP - 159

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 1

ER -