Genetic association analysis of NOS1 and methamphetamine-induced psychosis among Japanese

Takenori Okumura, Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Tomoko Tsunoka, Yasuhisa Fukuo, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

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1 Citation (Scopus)

Abstract

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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