TY - JOUR
T1 - Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese
AU - Okochi, T.
AU - Kishi, T.
AU - Ikeda, M.
AU - Kitajima, T.
AU - Kinoshita, Y.
AU - Kawashima, K.
AU - Okumura, T.
AU - Tsunoka, T.
AU - Fukuo, Y.
AU - Inada, T.
AU - Yamada, M.
AU - Uchimura, N.
AU - Iyo, M.
AU - Sora, I.
AU - Ozaki, N.
AU - Ujike, H.
AU - Iwata, N.
PY - 2011
Y1 - 2011
N2 - Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
AB - Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
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U2 - 10.2174/157015911795017119
DO - 10.2174/157015911795017119
M3 - Article
C2 - 21886581
AN - SCOPUS:79953037835
SN - 1570-159X
VL - 9
SP - 151
EP - 154
JO - Current Neuropharmacology
JF - Current Neuropharmacology
IS - 1
ER -
