Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese

T. Okochi, T. Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Y. Kinoshita, K. Kawashima, T. Okumura, T. Tsunoka, Y. Fukuo, T. Inada, M. Yamada, N. Uchimura, M. Iyo, I. Sora, N. Ozaki, H. Ujike, Nakao Iwata

Research output: Contribution to journalArticle

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Abstract

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

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Methamphetamine
Psychotic Disorders
Nitric Oxide
Single Nucleotide Polymorphism
Nitric Oxide Synthase Type III
N-Methyl-D-Aspartate Receptors
Informed Consent
Haplotypes
Neurotransmitter Agents
Case-Control Studies
Oxidative Stress
Central Nervous System
Alleles
Genotype
Pharmacology
Brain
Enzymes
Population
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Okochi, T. ; Kishi, T. ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Kinoshita, Y. ; Kawashima, K. ; Okumura, T. ; Tsunoka, T. ; Fukuo, Y. ; Inada, T. ; Yamada, M. ; Uchimura, N. ; Iyo, M. ; Sora, I. ; Ozaki, N. ; Ujike, H. ; Iwata, Nakao. / Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 151-154.
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author = "T. Okochi and T. Kishi and Masashi Ikeda and Tsuyoshi Kitajima and Y. Kinoshita and K. Kawashima and T. Okumura and T. Tsunoka and Y. Fukuo and T. Inada and M. Yamada and N. Uchimura and M. Iyo and I. Sora and N. Ozaki and H. Ujike and Nakao Iwata",
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Okochi, T, Kishi, T, Ikeda, M, Kitajima, T, Kinoshita, Y, Kawashima, K, Okumura, T, Tsunoka, T, Fukuo, Y, Inada, T, Yamada, M, Uchimura, N, Iyo, M, Sora, I, Ozaki, N, Ujike, H & Iwata, N 2011, 'Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese', Current Neuropharmacology, vol. 9, no. 1, pp. 151-154. https://doi.org/10.2174/157015911795017119

Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese. / Okochi, T.; Kishi, T.; Ikeda, Masashi; Kitajima, Tsuyoshi; Kinoshita, Y.; Kawashima, K.; Okumura, T.; Tsunoka, T.; Fukuo, Y.; Inada, T.; Yamada, M.; Uchimura, N.; Iyo, M.; Sora, I.; Ozaki, N.; Ujike, H.; Iwata, Nakao.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 151-154.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic association analysis of NOS3 and methamphetamine-induced psychosis among Japanese

AU - Okochi, T.

AU - Kishi, T.

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Kinoshita, Y.

AU - Kawashima, K.

AU - Okumura, T.

AU - Tsunoka, T.

AU - Fukuo, Y.

AU - Inada, T.

AU - Yamada, M.

AU - Uchimura, N.

AU - Iyo, M.

AU - Sora, I.

AU - Ozaki, N.

AU - Ujike, H.

AU - Iwata, Nakao

PY - 2011/3/30

Y1 - 2011/3/30

N2 - Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

AB - Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

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