Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population

Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Takenori Okumura, Tomoko Tsunoka, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Original languageEnglish
Pages (from-to)903-905
Number of pages3
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number5
DOIs
Publication statusPublished - 01-08-2009

Fingerprint

Neuregulin-1
Methamphetamine
Psychotic Disorders
Population
Genes
Schizophrenia
Informed Consent
Haplotypes
Single Nucleotide Polymorphism
Case-Control Studies
Glutamic Acid
Alleles
Genotype

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Okochi, Tomo ; Kishi, Taro ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Okumura, Takenori ; Tsunoka, Tomoko ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Ujike, Hiroshi ; Iwata, Nakao. / Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009 ; Vol. 33, No. 5. pp. 903-905.
@article{c4ecc24ad4f94da8b7ec3b988407faa5,
title = "Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population",
abstract = "The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.",
author = "Tomo Okochi and Taro Kishi and Masashi Ikeda and Tsuyoshi Kitajima and Yoko Kinoshita and Kunihiro Kawashima and Takenori Okumura and Tomoko Tsunoka and Toshiya Inada and Mitsuhiko Yamada and Naohisa Uchimura and Masaomi Iyo and Ichiro Sora and Norio Ozaki and Hiroshi Ujike and Nakao Iwata",
year = "2009",
month = "8",
day = "1",
doi = "10.1016/j.pnpbp.2009.04.016",
language = "English",
volume = "33",
pages = "903--905",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "5",

}

Okochi, T, Kishi, T, Ikeda, M, Kitajima, T, Kinoshita, Y, Kawashima, K, Okumura, T, Tsunoka, T, Inada, T, Yamada, M, Uchimura, N, Iyo, M, Sora, I, Ozaki, N, Ujike, H & Iwata, N 2009, 'Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 5, pp. 903-905. https://doi.org/10.1016/j.pnpbp.2009.04.016

Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. / Okochi, Tomo; Kishi, Taro; Ikeda, Masashi; Kitajima, Tsuyoshi; Kinoshita, Yoko; Kawashima, Kunihiro; Okumura, Takenori; Tsunoka, Tomoko; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Ujike, Hiroshi; Iwata, Nakao.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 5, 01.08.2009, p. 903-905.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population

AU - Okochi, Tomo

AU - Kishi, Taro

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Okumura, Takenori

AU - Tsunoka, Tomoko

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Ujike, Hiroshi

AU - Iwata, Nakao

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

AB - The neuregulin 1 gene (NRG1) has been identified as a candidate gene for schizophrenia in a linkage study in the Icelandic population. Recent evidence also suggested that it might be related to the neurodevelopmental hypothesis and glutamate hypothesis for schizophrenia. Because the symptomatology of methamphetamine (METH) use disorder with accompanying psychosis is similar to that of patients with schizophrenia, NRG1 is an appropriate candidate gene for METH-induced psychosis. We conducted a case-control association study between NRG1 and METH-induced psychosis in a Japanese population (184 subjects with METH-induced psychosis and 534 controls). Written informed consent was obtained from each subject. We selected four SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177, and rs3924999) in NRG1 from previous reports. No significant association was found between NRG1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, NRG1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=67649202214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649202214&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2009.04.016

DO - 10.1016/j.pnpbp.2009.04.016

M3 - Article

VL - 33

SP - 903

EP - 905

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 5

ER -