Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population

Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Toshiya Inada, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Because several investigations, including genetic studies, have reported associations between serotonin (5-HT) 2A receptor gene and mood disorders, 5-HT 2A receptor gene (HTR2A) is a good candidate gene for the pathophysiology of mood disorders such as major depressive disorder (MDD) and bipolar disorder (BP). Using two functional SNPs (T102C and -A1438G) and two SNPs (rs7997012 and rs1928040) in HTR2A, which reported an association with therapeutic response to the SSRI, we conducted a genetic association analysis of case-control samples (325 MDD patients, 155 BP patients and 802 controls) in the Japanese population. We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis. In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and mood disorders in the Japanese population, but sample sizes, especially BP, were probably too small to allow a meaningful test. Crown

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalNeuroscience Research
Volume64
Issue number2
DOIs
Publication statusPublished - 01-06-2009

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Receptor, Serotonin, 5-HT2A
Major Depressive Disorder
Bipolar Disorder
Mood Disorders
Population
Genes
Single Nucleotide Polymorphism
Population Density
Crowns
Sample Size
Haplotypes
Serotonin
Alleles
Genotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kishi, Taro ; Kitajima, Tsuyoshi ; Tsunoka, Tomoko ; Ikeda, Masashi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Okochi, Tomo ; Okumura, Takenori ; Inada, Toshiya ; Ozaki, Norio ; Iwata, Nakao. / Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. In: Neuroscience Research. 2009 ; Vol. 64, No. 2. pp. 231-234.
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Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population. / Kishi, Taro; Kitajima, Tsuyoshi; Tsunoka, Tomoko; Ikeda, Masashi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Okochi, Tomo; Okumura, Takenori; Inada, Toshiya; Ozaki, Norio; Iwata, Nakao.

In: Neuroscience Research, Vol. 64, No. 2, 01.06.2009, p. 231-234.

Research output: Contribution to journalArticle

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AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Tsunoka, Tomoko

AU - Ikeda, Masashi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Okumura, Takenori

AU - Inada, Toshiya

AU - Ozaki, Norio

AU - Iwata, Nakao

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