Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population

Yusuke Kajio, Kenji Kondo, Takeo Saito, Yoshimi Iwayama, Branko Aleksic, Kazuo Yamada, Tomoko Toyota, Eiji Hattori, Hiroshi Ujike, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Norio Ozaki, Masashi Ikeda, Nakao Iwata

Research output: Contribution to journalArticle

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Abstract

Several epidemiological and genetic studies have suggested that the risk of type II diabetes (T2D) is likely to overlap with the susceptibility to psychotic disorders such as schizophrenia (SCZ) and bipolar disorder (BD). In this study, we aimed to examine the association of single-nucleotide polymorphisms (SNPs) detected in previous T2D genome-wide association studies (GWAS) with SCZ, BD and psychosis (SCZ plus BD). A total of 37 SNPs were selected from the literature. A two-stage analysis was conducted using a first set of screening samples (total N=3037) and a second set of replication samples (N=4950). None of the SNPs showed a significant association to the screening samples after correction for multiple testing. To avoid type II error, we genotyped the top three SNPs in BCL11A, HMG20A and HNF4A showing associations with any of the phenotypes (P uncorrected <0.01) using independent samples to replicate the nominal associations. However, we were unable to find any significant associations based on the screening results (P uncorrected >0.05). Our findings did not support the shared genetic risk between T2D and psychotic disorders in the Japanese population. However, further replication using a larger sample size is required.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalJournal of Human Genetics
Volume59
Issue number1
DOIs
Publication statusPublished - 01-01-2014

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Genome-Wide Association Study
Genetic Association Studies
Psychotic Disorders
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Bipolar Disorder
Schizophrenia
Population
Sample Size
Epidemiologic Studies
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Kajio, Yusuke ; Kondo, Kenji ; Saito, Takeo ; Iwayama, Yoshimi ; Aleksic, Branko ; Yamada, Kazuo ; Toyota, Tomoko ; Hattori, Eiji ; Ujike, Hiroshi ; Inada, Toshiya ; Kunugi, Hiroshi ; Kato, Tadafumi ; Yoshikawa, Takeo ; Ozaki, Norio ; Ikeda, Masashi ; Iwata, Nakao. / Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population. In: Journal of Human Genetics. 2014 ; Vol. 59, No. 1. pp. 54-56.
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Kajio, Y, Kondo, K, Saito, T, Iwayama, Y, Aleksic, B, Yamada, K, Toyota, T, Hattori, E, Ujike, H, Inada, T, Kunugi, H, Kato, T, Yoshikawa, T, Ozaki, N, Ikeda, M & Iwata, N 2014, 'Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population', Journal of Human Genetics, vol. 59, no. 1, pp. 54-56. https://doi.org/10.1038/jhg.2013.116

Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population. / Kajio, Yusuke; Kondo, Kenji; Saito, Takeo; Iwayama, Yoshimi; Aleksic, Branko; Yamada, Kazuo; Toyota, Tomoko; Hattori, Eiji; Ujike, Hiroshi; Inada, Toshiya; Kunugi, Hiroshi; Kato, Tadafumi; Yoshikawa, Takeo; Ozaki, Norio; Ikeda, Masashi; Iwata, Nakao.

In: Journal of Human Genetics, Vol. 59, No. 1, 01.01.2014, p. 54-56.

Research output: Contribution to journalArticle

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T1 - Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population

AU - Kajio, Yusuke

AU - Kondo, Kenji

AU - Saito, Takeo

AU - Iwayama, Yoshimi

AU - Aleksic, Branko

AU - Yamada, Kazuo

AU - Toyota, Tomoko

AU - Hattori, Eiji

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Kunugi, Hiroshi

AU - Kato, Tadafumi

AU - Yoshikawa, Takeo

AU - Ozaki, Norio

AU - Ikeda, Masashi

AU - Iwata, Nakao

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Several epidemiological and genetic studies have suggested that the risk of type II diabetes (T2D) is likely to overlap with the susceptibility to psychotic disorders such as schizophrenia (SCZ) and bipolar disorder (BD). In this study, we aimed to examine the association of single-nucleotide polymorphisms (SNPs) detected in previous T2D genome-wide association studies (GWAS) with SCZ, BD and psychosis (SCZ plus BD). A total of 37 SNPs were selected from the literature. A two-stage analysis was conducted using a first set of screening samples (total N=3037) and a second set of replication samples (N=4950). None of the SNPs showed a significant association to the screening samples after correction for multiple testing. To avoid type II error, we genotyped the top three SNPs in BCL11A, HMG20A and HNF4A showing associations with any of the phenotypes (P uncorrected <0.01) using independent samples to replicate the nominal associations. However, we were unable to find any significant associations based on the screening results (P uncorrected >0.05). Our findings did not support the shared genetic risk between T2D and psychotic disorders in the Japanese population. However, further replication using a larger sample size is required.

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