Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Branko Aleksic, Itaru Kushima, Yoshihito Ito, Yukako Nakamura, Hiroshi Ujike, Michio Suzuki, Toshiya Inada, Ryota Hashimoto, Masatoshi Takeda, Nakao Iwata, Norio Ozaki

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Abstract

The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalSchizophrenia Research
Volume118
Issue number1-3
DOIs
Publication statusPublished - 01-05-2010

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Aleksic, B., Kushima, I., Ito, Y., Nakamura, Y., Ujike, H., Suzuki, M., Inada, T., Hashimoto, R., Takeda, M., Iwata, N., & Ozaki, N. (2010). Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophrenia Research, 118(1-3), 113-117. https://doi.org/10.1016/j.schres.2010.01.014