TY - JOUR
T1 - Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
AU - Aleksic, Branko
AU - Kushima, Itaru
AU - Ito, Yoshihito
AU - Nakamura, Yukako
AU - Ujike, Hiroshi
AU - Suzuki, Michio
AU - Inada, Toshiya
AU - Hashimoto, Ryota
AU - Takeda, Masatoshi
AU - Iwata, Nakao
AU - Ozaki, Norio
N1 - Funding Information:
Funding for this study was provided by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Ministry of Health, Labor and Welfare of Japan; Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan; The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes; and the Core Research for Evolutional Science and Technology. These institutions had no further role in the study design; the collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit the paper for publication.
PY - 2010/5
Y1 - 2010/5
N2 - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.
AB - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=77951976760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951976760&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2010.01.014
DO - 10.1016/j.schres.2010.01.014
M3 - Article
C2 - 20153141
AN - SCOPUS:77951976760
SN - 0920-9964
VL - 118
SP - 113
EP - 117
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
