Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Branko Aleksic; Itaru Kushima; Yoshihito Ito; Yukako Nakamura; Hiroshi Ujike; Michio Suzuki; Toshiya Inada; Ryota Hashimoto; Masatoshi Takeda; Nakao Iwata; Norio Ozaki

doi:10.1016/j.schres.2010.01.014

Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Branko Aleksic
, Itaru Kushima
, Yoshihito Ito
, Yukako Nakamura
, Hiroshi Ujike
, Michio Suzuki
, Toshiya Inada
, Ryota Hashimoto
, Masatoshi Takeda
, Nakao Iwata
, Norio Ozaki

Psychiatry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Schizophrenia Research
Volume	118
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2010.01.014
Publication status	Published - 05-2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2010.01.014

Cite this

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title = "Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population",

abstract = "The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.",

author = "Branko Aleksic and Itaru Kushima and Yoshihito Ito and Yukako Nakamura and Hiroshi Ujike and Michio Suzuki and Toshiya Inada and Ryota Hashimoto and Masatoshi Takeda and Nakao Iwata and Norio Ozaki",

note = "Funding Information: Funding for this study was provided by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Ministry of Health, Labor and Welfare of Japan; Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan; The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes; and the Core Research for Evolutional Science and Technology. These institutions had no further role in the study design; the collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit the paper for publication. ",

year = "2010",

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doi = "10.1016/j.schres.2010.01.014",

language = "English",

volume = "118",

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journal = "Schizophrenia Research",

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TY - JOUR

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AU - Aleksic, Branko

AU - Kushima, Itaru

AU - Ito, Yoshihito

AU - Nakamura, Yukako

AU - Ujike, Hiroshi

AU - Suzuki, Michio

AU - Inada, Toshiya

AU - Hashimoto, Ryota

AU - Takeda, Masatoshi

AU - Iwata, Nakao

AU - Ozaki, Norio

N1 - Funding Information: Funding for this study was provided by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Ministry of Health, Labor and Welfare of Japan; Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan; The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes; and the Core Research for Evolutional Science and Technology. These institutions had no further role in the study design; the collection, analysis, and interpretation of the data; the writing of this report; or the decision to submit the paper for publication.

PY - 2010/5

Y1 - 2010/5

N2 - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

AB - The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

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UR - https://www.scopus.com/pages/publications/77951976760#tab=citedBy

U2 - 10.1016/j.schres.2010.01.014

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M3 - Article

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JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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