Genetic characterization of adult infratentorial gliomas

Tomoru Miwa, Yuichi Hirose, Hikaru Sasaki, Eiji Ikeda, Kazunari Yoshida, Takeshi Kawase

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Adult infratentorial gliomas are rare and have not been well studied. We therefore conducted genetic analysis of those tumors to see if there was any characteristic that could be relevant in clinical management and understanding of tumorigenesis. Nineteen adult infratentorial gliomas were analyzed for chromosomal aberration by comparative genomic hybridization, and for expression of p53 and epidermal growth factor receptor (EGFR) by immunohistochemistry. The most frequent chromosomal aberration was the gain of 7p, and five of the seven cerebellar or fourth ventricle malignant gliomas had that aberration. However, the gain of 7q, the characteristic abnormality of supratentorial astrocytomas commonly associated with the gaining of 7p, was observed only in 1 of 11 adult infratentorial astrocytic tumors. Combined losses of 1p and 19q, the genetic hallmark of oligodendroglioma, were not observed. Results of immunohistochemistry of p53 and EGFR were comparable to those reported in supratentorial gliomas. Our findings might suggest the presence of distinct tumorigenic pathway in adult infratentorial gliomas.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJournal of Neuro-Oncology
Volume91
Issue number3
DOIs
Publication statusPublished - 01-01-2009

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Glioma
Epidermal Growth Factor Receptor
Chromosome Aberrations
Immunohistochemistry
Infratentorial Neoplasms
Oligodendroglioma
Fourth Ventricle
Comparative Genomic Hybridization
Astrocytoma
Carcinogenesis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Miwa, Tomoru ; Hirose, Yuichi ; Sasaki, Hikaru ; Ikeda, Eiji ; Yoshida, Kazunari ; Kawase, Takeshi. / Genetic characterization of adult infratentorial gliomas. In: Journal of Neuro-Oncology. 2009 ; Vol. 91, No. 3. pp. 251-255.
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Miwa, T, Hirose, Y, Sasaki, H, Ikeda, E, Yoshida, K & Kawase, T 2009, 'Genetic characterization of adult infratentorial gliomas', Journal of Neuro-Oncology, vol. 91, no. 3, pp. 251-255. https://doi.org/10.1007/s11060-008-9714-2

Genetic characterization of adult infratentorial gliomas. / Miwa, Tomoru; Hirose, Yuichi; Sasaki, Hikaru; Ikeda, Eiji; Yoshida, Kazunari; Kawase, Takeshi.

In: Journal of Neuro-Oncology, Vol. 91, No. 3, 01.01.2009, p. 251-255.

Research output: Contribution to journalArticle

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