Genetic effects on white matter integrity in drug-naive patients with major depressive disorder

A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

Shingo Kakeda, Keita Watanabe, Asuka Katsuki, Koichiro Sugimoto, Issei Ueda, Natsuki Igata, Taro Kishi, Nakao Iwata, Osamu Abe, Reiji Yoshimura, Yukunori Korogi

Research output: Contribution to journalArticle

Abstract

Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalNeuropsychiatric Disease and Treatment
Volume15
DOIs
Publication statusPublished - 01-01-2019

Fingerprint

Diffusion Tensor Imaging
Genetic Loci
Major Depressive Disorder
Depression
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Surgical Instruments
Genes
Pyramidal Tracts
Dipeptides
Genome-Wide Association Study
White Matter
Healthy Volunteers
Genotype
Radiation
Acids

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Kakeda, Shingo ; Watanabe, Keita ; Katsuki, Asuka ; Sugimoto, Koichiro ; Ueda, Issei ; Igata, Natsuki ; Kishi, Taro ; Iwata, Nakao ; Abe, Osamu ; Yoshimura, Reiji ; Korogi, Yukunori. / Genetic effects on white matter integrity in drug-naive patients with major depressive disorder : A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms. In: Neuropsychiatric Disease and Treatment. 2019 ; Vol. 15. pp. 375-383.
@article{e5e0a24d0d4a4f19a4400312175ef5d9,
title = "Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms",
abstract = "Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.",
author = "Shingo Kakeda and Keita Watanabe and Asuka Katsuki and Koichiro Sugimoto and Issei Ueda and Natsuki Igata and Taro Kishi and Nakao Iwata and Osamu Abe and Reiji Yoshimura and Yukunori Korogi",
year = "2019",
month = "1",
day = "1",
doi = "10.2147/NDT.S190268",
language = "English",
volume = "15",
pages = "375--383",
journal = "Neuropsychiatric Disease and Treatment",
issn = "1176-6328",
publisher = "Dove Medical Press Ltd.",

}

Genetic effects on white matter integrity in drug-naive patients with major depressive disorder : A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms. / Kakeda, Shingo; Watanabe, Keita; Katsuki, Asuka; Sugimoto, Koichiro; Ueda, Issei; Igata, Natsuki; Kishi, Taro; Iwata, Nakao; Abe, Osamu; Yoshimura, Reiji; Korogi, Yukunori.

In: Neuropsychiatric Disease and Treatment, Vol. 15, 01.01.2019, p. 375-383.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic effects on white matter integrity in drug-naive patients with major depressive disorder

T2 - A diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

AU - Kakeda, Shingo

AU - Watanabe, Keita

AU - Katsuki, Asuka

AU - Sugimoto, Koichiro

AU - Ueda, Issei

AU - Igata, Natsuki

AU - Kishi, Taro

AU - Iwata, Nakao

AU - Abe, Osamu

AU - Yoshimura, Reiji

AU - Korogi, Yukunori

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.

AB - Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Methods: Thirty-five drug-naive MDD patients with a first depressive episode and 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans and genotyping. The genotype–diagnosis interactions related to WM integrity were evaluated using TBSS for the 17 SNPs. Results: For the anterior thalamic radiation, cingulum, corticospinal tract, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, forceps major, and forceps minor, the genotype effect significantly differed between diagnosis groups (P<0.05, family-wise error corrected) in only one SNP, rs301806, in the arginine–glutamic acid dipeptide (RE) repeats (RERE) gene. Conclusion: The RERE polymorphism was associated with WM alterations in first-episode and drug-naive MDD patients, which may be at least partially related to the manifestation of MDD. Future studies are needed to explore the gene–environment interactions with regard to individual WM integrity.

UR - http://www.scopus.com/inward/record.url?scp=85062673603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062673603&partnerID=8YFLogxK

U2 - 10.2147/NDT.S190268

DO - 10.2147/NDT.S190268

M3 - Article

VL - 15

SP - 375

EP - 383

JO - Neuropsychiatric Disease and Treatment

JF - Neuropsychiatric Disease and Treatment

SN - 1176-6328

ER -