Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer

Tomiyasu Arisawa, Tomomitsu Tahara, Hisakazu Shiroeda, Yasuhito Matsue, Takahiro Minato, Tomoe Nomura, Hideto Yamada, Ranji Hayashi, Takashi Saito, Kazuhiro Matsunaga, Tomoki Fukuyama, Nobuhiko Hayashi, Toshimi Otsuka, Atsushi Fukumura, Masakatsu Nakamura, Tomoyuki Shibata

Research output: Contribution to journalArticle

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Abstract

We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G>A), rs3748067 ( *1249 C>T), and pri-miR-938, rs2505901 (T>C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95%CI, 1.63-3.46; p<0.0001) for the development of both intestinal and diffuse types of GC. The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95%CI, 0.272-0.962; p=0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95%CI, 0.545-0.985; p=0.039). In addition, rs3748067 T allele was inversely correlated with lymph node metastasis. Our results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalHuman Immunology
Volume73
Issue number7
DOIs
Publication statusPublished - 01-07-2012

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3' Untranslated Regions
Genetic Polymorphisms
MicroRNAs
Stomach Neoplasms
Intestinal Neoplasms
Single-Stranded Conformational Polymorphism
Multiplex Polymerase Chain Reaction
Homozygote
Gene Frequency
Lymph Nodes
Alleles
Neoplasm Metastasis
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Arisawa, Tomiyasu ; Tahara, Tomomitsu ; Shiroeda, Hisakazu ; Matsue, Yasuhito ; Minato, Takahiro ; Nomura, Tomoe ; Yamada, Hideto ; Hayashi, Ranji ; Saito, Takashi ; Matsunaga, Kazuhiro ; Fukuyama, Tomoki ; Hayashi, Nobuhiko ; Otsuka, Toshimi ; Fukumura, Atsushi ; Nakamura, Masakatsu ; Shibata, Tomoyuki. / Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer. In: Human Immunology. 2012 ; Vol. 73, No. 7. pp. 747-752.
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abstract = "We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G>A), rs3748067 ( *1249 C>T), and pri-miR-938, rs2505901 (T>C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95{\%}CI, 1.63-3.46; p<0.0001) for the development of both intestinal and diffuse types of GC. The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95{\%}CI, 0.272-0.962; p=0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95{\%}CI, 0.545-0.985; p=0.039). In addition, rs3748067 T allele was inversely correlated with lymph node metastasis. Our results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.",
author = "Tomiyasu Arisawa and Tomomitsu Tahara and Hisakazu Shiroeda and Yasuhito Matsue and Takahiro Minato and Tomoe Nomura and Hideto Yamada and Ranji Hayashi and Takashi Saito and Kazuhiro Matsunaga and Tomoki Fukuyama and Nobuhiko Hayashi and Toshimi Otsuka and Atsushi Fukumura and Masakatsu Nakamura and Tomoyuki Shibata",
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Arisawa, T, Tahara, T, Shiroeda, H, Matsue, Y, Minato, T, Nomura, T, Yamada, H, Hayashi, R, Saito, T, Matsunaga, K, Fukuyama, T, Hayashi, N, Otsuka, T, Fukumura, A, Nakamura, M & Shibata, T 2012, 'Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer', Human Immunology, vol. 73, no. 7, pp. 747-752. https://doi.org/10.1016/j.humimm.2012.04.011

Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer. / Arisawa, Tomiyasu; Tahara, Tomomitsu; Shiroeda, Hisakazu; Matsue, Yasuhito; Minato, Takahiro; Nomura, Tomoe; Yamada, Hideto; Hayashi, Ranji; Saito, Takashi; Matsunaga, Kazuhiro; Fukuyama, Tomoki; Hayashi, Nobuhiko; Otsuka, Toshimi; Fukumura, Atsushi; Nakamura, Masakatsu; Shibata, Tomoyuki.

In: Human Immunology, Vol. 73, No. 7, 01.07.2012, p. 747-752.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer

AU - Arisawa, Tomiyasu

AU - Tahara, Tomomitsu

AU - Shiroeda, Hisakazu

AU - Matsue, Yasuhito

AU - Minato, Takahiro

AU - Nomura, Tomoe

AU - Yamada, Hideto

AU - Hayashi, Ranji

AU - Saito, Takashi

AU - Matsunaga, Kazuhiro

AU - Fukuyama, Tomoki

AU - Hayashi, Nobuhiko

AU - Otsuka, Toshimi

AU - Fukumura, Atsushi

AU - Nakamura, Masakatsu

AU - Shibata, Tomoyuki

PY - 2012/7/1

Y1 - 2012/7/1

N2 - We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G>A), rs3748067 ( *1249 C>T), and pri-miR-938, rs2505901 (T>C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95%CI, 1.63-3.46; p<0.0001) for the development of both intestinal and diffuse types of GC. The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95%CI, 0.272-0.962; p=0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95%CI, 0.545-0.985; p=0.039). In addition, rs3748067 T allele was inversely correlated with lymph node metastasis. Our results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.

AB - We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G>A), rs3748067 ( *1249 C>T), and pri-miR-938, rs2505901 (T>C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95%CI, 1.63-3.46; p<0.0001) for the development of both intestinal and diffuse types of GC. The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95%CI, 0.272-0.962; p=0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95%CI, 0.545-0.985; p=0.039). In addition, rs3748067 T allele was inversely correlated with lymph node metastasis. Our results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.

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