Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

Tomiyasu Arisawa, Masakatsu Nakamura, Toshimi Otsuka, Wu Jing, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomomitsu Tahara, Tomoyuki Shibata

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Abstract

Aim: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. Methods: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). Results: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. Conclusion: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

Original languageEnglish
Pages (from-to)5364-5370
Number of pages7
JournalWorld Journal of Gastroenterology
Volume23
Issue number29
DOIs
Publication statusPublished - 07-08-2017

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Maf Transcription Factors
Genetic Polymorphisms
Ulcerative Colitis
Japan
Genotype
Single Nucleotide Polymorphism
protein K
Gastrointestinal Hemorrhage
Dyskinesias
Gene Frequency
Case-Control Studies
Diarrhea

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Arisawa, Tomiyasu ; Nakamura, Masakatsu ; Otsuka, Toshimi ; Jing, Wu ; Sakurai, Naoko ; Takano, Hikaru ; Hayashi, Tasuku ; Ota, Masafumi ; Nomura, Tomoe ; Hayashi, Ranji ; Shimasaki, Takeo ; Tahara, Tomomitsu ; Shibata, Tomoyuki. / Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan. In: World Journal of Gastroenterology. 2017 ; Vol. 23, No. 29. pp. 5364-5370.
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abstract = "Aim: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. Methods: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). Results: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95{\%}CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95{\%}CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. Conclusion: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.",
author = "Tomiyasu Arisawa and Masakatsu Nakamura and Toshimi Otsuka and Wu Jing and Naoko Sakurai and Hikaru Takano and Tasuku Hayashi and Masafumi Ota and Tomoe Nomura and Ranji Hayashi and Takeo Shimasaki and Tomomitsu Tahara and Tomoyuki Shibata",
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Arisawa, T, Nakamura, M, Otsuka, T, Jing, W, Sakurai, N, Takano, H, Hayashi, T, Ota, M, Nomura, T, Hayashi, R, Shimasaki, T, Tahara, T & Shibata, T 2017, 'Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan', World Journal of Gastroenterology, vol. 23, no. 29, pp. 5364-5370. https://doi.org/10.3748/wjg.v23.i29.5364

Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan. / Arisawa, Tomiyasu; Nakamura, Masakatsu; Otsuka, Toshimi; Jing, Wu; Sakurai, Naoko; Takano, Hikaru; Hayashi, Tasuku; Ota, Masafumi; Nomura, Tomoe; Hayashi, Ranji; Shimasaki, Takeo; Tahara, Tomomitsu; Shibata, Tomoyuki.

In: World Journal of Gastroenterology, Vol. 23, No. 29, 07.08.2017, p. 5364-5370.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

AU - Arisawa, Tomiyasu

AU - Nakamura, Masakatsu

AU - Otsuka, Toshimi

AU - Jing, Wu

AU - Sakurai, Naoko

AU - Takano, Hikaru

AU - Hayashi, Tasuku

AU - Ota, Masafumi

AU - Nomura, Tomoe

AU - Hayashi, Ranji

AU - Shimasaki, Takeo

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

PY - 2017/8/7

Y1 - 2017/8/7

N2 - Aim: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. Methods: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). Results: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. Conclusion: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

AB - Aim: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. Methods: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). Results: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. Conclusion: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

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DO - 10.3748/wjg.v23.i29.5364

M3 - Article

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JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

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