Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (abcg2, abcb1) and gefitinib toxicity

Mariko Tamura, Masashi Kondo, Mihoko Horio, Maki Ando, Hiroshi Saito, Masashi Yamamoto, Yoshitsugu Horio, Yoshinori Hasegawa

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Abstract

The purpose of this study is to investigate associations between allelic variations of ABCG2 and ABCB1 with skin toxicity, diarrhea, liver injury and interstitial lung disease (ILD) in gefitinib-treated patients. A prospective clinical study of 83 Japanese patients with non-small-cell lung cancer was performed. Polymorphic loci in ABCG2 and ABCB1 were genotyped, and their effects on gefitinib toxicities were evaluated. ABCG2 34G>A was statistically associated with occurrence of skin rash; 13 (42%) of the 32 patients with at least one variant ABCG2 34G>A allele (G/A and A/A) developed grade 2 or worse skin rash, whereas only 10 (19%) of 51 patients homozygous for the reference allele (G/G) for the wild-type sequence for both alleles did so (P = 0.046). There was no significant association between severe toxicities and polymorphisms of ABCG2 421C>A nor ABCB1 3435C>T. The results suggested that ABCG2 34G>A would be useful for predicting grade 2 or worse skin rash.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalNagoya Journal of Medical Science
Volume74
Issue number1-2
Publication statusPublished - 01-12-2012

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Genetic Polymorphisms
Adenosine Triphosphate
Exanthema
Alleles
Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Diarrhea
Prospective Studies
Skin
gefitinib
Liver
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Tamura, Mariko ; Kondo, Masashi ; Horio, Mihoko ; Ando, Maki ; Saito, Hiroshi ; Yamamoto, Masashi ; Horio, Yoshitsugu ; Hasegawa, Yoshinori. / Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (abcg2, abcb1) and gefitinib toxicity. In: Nagoya Journal of Medical Science. 2012 ; Vol. 74, No. 1-2. pp. 133-140.
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abstract = "The purpose of this study is to investigate associations between allelic variations of ABCG2 and ABCB1 with skin toxicity, diarrhea, liver injury and interstitial lung disease (ILD) in gefitinib-treated patients. A prospective clinical study of 83 Japanese patients with non-small-cell lung cancer was performed. Polymorphic loci in ABCG2 and ABCB1 were genotyped, and their effects on gefitinib toxicities were evaluated. ABCG2 34G>A was statistically associated with occurrence of skin rash; 13 (42{\%}) of the 32 patients with at least one variant ABCG2 34G>A allele (G/A and A/A) developed grade 2 or worse skin rash, whereas only 10 (19{\%}) of 51 patients homozygous for the reference allele (G/G) for the wild-type sequence for both alleles did so (P = 0.046). There was no significant association between severe toxicities and polymorphisms of ABCG2 421C>A nor ABCB1 3435C>T. The results suggested that ABCG2 34G>A would be useful for predicting grade 2 or worse skin rash.",
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Tamura, M, Kondo, M, Horio, M, Ando, M, Saito, H, Yamamoto, M, Horio, Y & Hasegawa, Y 2012, 'Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (abcg2, abcb1) and gefitinib toxicity', Nagoya Journal of Medical Science, vol. 74, no. 1-2, pp. 133-140.

Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (abcg2, abcb1) and gefitinib toxicity. / Tamura, Mariko; Kondo, Masashi; Horio, Mihoko; Ando, Maki; Saito, Hiroshi; Yamamoto, Masashi; Horio, Yoshitsugu; Hasegawa, Yoshinori.

In: Nagoya Journal of Medical Science, Vol. 74, No. 1-2, 01.12.2012, p. 133-140.

Research output: Contribution to journalArticle

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AU - Tamura, Mariko

AU - Kondo, Masashi

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AU - Saito, Hiroshi

AU - Yamamoto, Masashi

AU - Horio, Yoshitsugu

AU - Hasegawa, Yoshinori

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