Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo, Mitsuhiro Saito, Shizuko Nagao, Shigeru Yagiu, Hisahide Takahashi, Hiroyuki Morita, Takako Matsuyama Morita, Mutsushi Matsuyama

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6 Citations (Scopus)


BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

Original languageEnglish
Pages (from-to)1258-1263
Number of pages6
JournalMuscle and Nerve
Issue number10
Publication statusPublished - 10-10-1997


All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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