Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo, Mitsuhiro Saito, Shizuko Nagao, Shigeru Yagiu, Hisahide Takahashi, Hiroyuki Morita, Takako Matsuyama Morita, Mutsushi Matsuyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

Original languageEnglish
Pages (from-to)1258-1263
Number of pages6
JournalMuscle and Nerve
Volume20
Issue number10
DOIs
Publication statusPublished - 10-10-1997

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Inbred BUF Rats
Muscular Atrophy
Muscles
Oculomotor Muscles
Dominant Genes
Skeletal Muscle
Incidence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Amo, Hiroyuki ; Saito, Mitsuhiro ; Nagao, Shizuko ; Yagiu, Shigeru ; Takahashi, Hisahide ; Morita, Hiroyuki ; Morita, Takako Matsuyama ; Matsuyama, Mutsushi. / Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats. In: Muscle and Nerve. 1997 ; Vol. 20, No. 10. pp. 1258-1263.
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Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats. / Amo, Hiroyuki; Saito, Mitsuhiro; Nagao, Shizuko; Yagiu, Shigeru; Takahashi, Hisahide; Morita, Hiroyuki; Morita, Takako Matsuyama; Matsuyama, Mutsushi.

In: Muscle and Nerve, Vol. 20, No. 10, 10.10.1997, p. 1258-1263.

Research output: Contribution to journalArticle

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