Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo; Mitsuhiro Saito; Shizuko Nagao; Shigeru Yagiu; Hisahide Takahashi; Hiroyuki Morita; Takako Matsuyama Morita; Mutsushi Matsuyama

doi:10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo, Mitsuhiro Saito, Shizuko Nagao, Shigeru Yagiu, Hisahide Takahashi, Hiroyuki Morita, Takako Matsuyama Morita, Mutsushi Matsuyama

Advanced Medical Research Center for Animal Models of Human Diseases

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

Original language	English
Pages (from-to)	1258-1263
Number of pages	6
Journal	Muscle and Nerve
Volume	20
Issue number	10
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B
Publication status	Published - 1997

All Science Journal Classification (ASJC) codes

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

Cite this

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title = "Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats",

abstract = "BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.",

author = "Hiroyuki Amo and Mitsuhiro Saito and Shizuko Nagao and Shigeru Yagiu and Hisahide Takahashi and Hiroyuki Morita and Morita, {Takako Matsuyama} and Mutsushi Matsuyama",

year = "1997",

doi = "10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B",

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AU - Amo, Hiroyuki

AU - Saito, Mitsuhiro

AU - Nagao, Shizuko

AU - Yagiu, Shigeru

AU - Takahashi, Hisahide

AU - Morita, Hiroyuki

AU - Morita, Takako Matsuyama

AU - Matsuyama, Mutsushi

PY - 1997

Y1 - 1997

N2 - BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

AB - BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

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Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Abstract

All Science Journal Classification (ASJC) codes

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