Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo; Mitsuhiro Saito; Shizuko Nagao; Shigeru Yagiu; Hisahide Takahashi; Hiroyuki Morita; Takako Matsuyama Morita; Mutsushi Matsuyama

doi:10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Hiroyuki Amo
, Mitsuhiro Saito
, Shizuko Nagao
, Shigeru Yagiu
, Hisahide Takahashi
, Hiroyuki Morita
, Takako Matsuyama Morita
, Mutsushi Matsuyama

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

Original language	English
Pages (from-to)	1258-1263
Number of pages	6
Journal	Muscle and Nerve
Volume	20
Issue number	10
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B
Publication status	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

Cite this

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title = "Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats",

abstract = "BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100\% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.",

author = "Hiroyuki Amo and Mitsuhiro Saito and Shizuko Nagao and Shigeru Yagiu and Hisahide Takahashi and Hiroyuki Morita and Morita, \{Takako Matsuyama\} and Mutsushi Matsuyama",

year = "1997",

doi = "10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B",

language = "English",

volume = "20",

pages = "1258--1263",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley \& Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

AU - Amo, Hiroyuki

AU - Saito, Mitsuhiro

AU - Nagao, Shizuko

AU - Yagiu, Shigeru

AU - Takahashi, Hisahide

AU - Morita, Hiroyuki

AU - Morita, Takako Matsuyama

AU - Matsuyama, Mutsushi

PY - 1997

Y1 - 1997

N2 - BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

AB - BUF/Mna strain rats spontaneously develop slowly progressing mild- moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/Mna strain with three other strains, ACl/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas- 2, determine the development of the muscle atrophy in these combinations of crosses.

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U2 - 10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

DO - 10.1002/(SICI)1097-4598(199710)20:10<1258::AID-MUS8>3.0.CO;2-B

M3 - Article

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AN - SCOPUS:0030770375

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IS - 10

ER -

Genetic regulation of slowly progressing mild muscle atrophy in fast- twitch muscles of BUF/Mna rats

Abstract

All Science Journal Classification (ASJC) codes

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