TY - JOUR
T1 - Genetic risk for restenosis after coronary balloon angioplasty
AU - Horibe, Hideki
AU - Yamada, Yoshiji
AU - Ichihara, Sahoko
AU - Watarai, Masato
AU - Yanase, Masanobu
AU - Takemoto, Kenji
AU - Shimizu, Seiji
AU - Izawa, Hideo
AU - Takatsu, Fumimaro
AU - Yokota, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M. Yokota), a grant from Mitsui Life Social Welfare Foundation (to M. Yokota), a grant from the Tokyo Biochemical Research Foundation (to H. Izawa), a grant from Japan Heart Foundation/Zeria Pharmaceutical Grant for Research on Molecular Cardiology (to H. Izawa), and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to Y. Yamada).
PY - 2004/5
Y1 - 2004/5
N2 - Plain old balloon angioplasty (POBA) is a useful therapeutic strategy especially for angioplasty of small coronary arteries. An association study was performed to identify genes that confer susceptibility to restenosis after POBA. The study population comprised 730 individuals (424 men, 306 women) who underwent successful POBA in at least one major coronary artery and were examined angiographically 6 months after the procedure. A total of 469 subjects (273 men, 196 women) exhibited no restenosis after POBA for any of the coronary lesions, whereas 261 subjects (151 men, 110 women) manifested restenosis for all lesions. The genotypes for 40 polymorphisms of 34 genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (242C → T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C → T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G → A in the paraoxonase 1 (PON1) gene and 2445G → A in the fatty acid-binding protein 2 (FABP2) gene) in women were significantly associated with restenosis after POBA. A stepwise forward selection procedure revealed that the effects of these polymorphisms on restenosis were statistically independent of conventional risk factors for coronary artery disease. Genotyping of these polymorphisms may prove informative for assessment of genetic risk for restenosis after POBA.
AB - Plain old balloon angioplasty (POBA) is a useful therapeutic strategy especially for angioplasty of small coronary arteries. An association study was performed to identify genes that confer susceptibility to restenosis after POBA. The study population comprised 730 individuals (424 men, 306 women) who underwent successful POBA in at least one major coronary artery and were examined angiographically 6 months after the procedure. A total of 469 subjects (273 men, 196 women) exhibited no restenosis after POBA for any of the coronary lesions, whereas 261 subjects (151 men, 110 women) manifested restenosis for all lesions. The genotypes for 40 polymorphisms of 34 genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (242C → T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C → T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G → A in the paraoxonase 1 (PON1) gene and 2445G → A in the fatty acid-binding protein 2 (FABP2) gene) in women were significantly associated with restenosis after POBA. A stepwise forward selection procedure revealed that the effects of these polymorphisms on restenosis were statistically independent of conventional risk factors for coronary artery disease. Genotyping of these polymorphisms may prove informative for assessment of genetic risk for restenosis after POBA.
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U2 - 10.1016/j.atherosclerosis.2004.01.022
DO - 10.1016/j.atherosclerosis.2004.01.022
M3 - Article
C2 - 15135268
AN - SCOPUS:2342649958
SN - 0021-9150
VL - 174
SP - 181
EP - 187
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -
