Genetic risk for restenosis after coronary balloon angioplasty

Hideki Horibe, Yoshiji Yamada, Sahoko Ichihara, Masato Watarai, Masanobu Yanase, Kenji Takemoto, Seiji Shimizu, Hideo Izawa, Fumimaro Takatsu, Mitsuhiro Yokota

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Plain old balloon angioplasty (POBA) is a useful therapeutic strategy especially for angioplasty of small coronary arteries. An association study was performed to identify genes that confer susceptibility to restenosis after POBA. The study population comprised 730 individuals (424 men, 306 women) who underwent successful POBA in at least one major coronary artery and were examined angiographically 6 months after the procedure. A total of 469 subjects (273 men, 196 women) exhibited no restenosis after POBA for any of the coronary lesions, whereas 261 subjects (151 men, 110 women) manifested restenosis for all lesions. The genotypes for 40 polymorphisms of 34 genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (242C → T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C → T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G → A in the paraoxonase 1 (PON1) gene and 2445G → A in the fatty acid-binding protein 2 (FABP2) gene) in women were significantly associated with restenosis after POBA. A stepwise forward selection procedure revealed that the effects of these polymorphisms on restenosis were statistically independent of conventional risk factors for coronary artery disease. Genotyping of these polymorphisms may prove informative for assessment of genetic risk for restenosis after POBA.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalAtherosclerosis
Volume174
Issue number1
DOIs
Publication statusPublished - 01-05-2004

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Coronary Balloon Angioplasty
Balloon Angioplasty
Genes
Coronary Vessels
Colorimetry
Aryldialkylphosphatase
Thrombomodulin
Fatty Acid-Binding Proteins
Hyperuricemia
DNA Primers
NADPH Oxidase
DNA Probes
Hypercholesterolemia
Angioplasty
Coronary Artery Disease
Diabetes Mellitus
Body Mass Index
Fluorescence
Logistic Models
Smoking

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Horibe, H., Yamada, Y., Ichihara, S., Watarai, M., Yanase, M., Takemoto, K., ... Yokota, M. (2004). Genetic risk for restenosis after coronary balloon angioplasty. Atherosclerosis, 174(1), 181-187. https://doi.org/10.1016/j.atherosclerosis.2004.01.022
Horibe, Hideki ; Yamada, Yoshiji ; Ichihara, Sahoko ; Watarai, Masato ; Yanase, Masanobu ; Takemoto, Kenji ; Shimizu, Seiji ; Izawa, Hideo ; Takatsu, Fumimaro ; Yokota, Mitsuhiro. / Genetic risk for restenosis after coronary balloon angioplasty. In: Atherosclerosis. 2004 ; Vol. 174, No. 1. pp. 181-187.
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Horibe, H, Yamada, Y, Ichihara, S, Watarai, M, Yanase, M, Takemoto, K, Shimizu, S, Izawa, H, Takatsu, F & Yokota, M 2004, 'Genetic risk for restenosis after coronary balloon angioplasty', Atherosclerosis, vol. 174, no. 1, pp. 181-187. https://doi.org/10.1016/j.atherosclerosis.2004.01.022

Genetic risk for restenosis after coronary balloon angioplasty. / Horibe, Hideki; Yamada, Yoshiji; Ichihara, Sahoko; Watarai, Masato; Yanase, Masanobu; Takemoto, Kenji; Shimizu, Seiji; Izawa, Hideo; Takatsu, Fumimaro; Yokota, Mitsuhiro.

In: Atherosclerosis, Vol. 174, No. 1, 01.05.2004, p. 181-187.

Research output: Contribution to journalArticle

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AU - Ichihara, Sahoko

AU - Watarai, Masato

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AU - Takemoto, Kenji

AU - Shimizu, Seiji

AU - Izawa, Hideo

AU - Takatsu, Fumimaro

AU - Yokota, Mitsuhiro

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Horibe H, Yamada Y, Ichihara S, Watarai M, Yanase M, Takemoto K et al. Genetic risk for restenosis after coronary balloon angioplasty. Atherosclerosis. 2004 May 1;174(1):181-187. https://doi.org/10.1016/j.atherosclerosis.2004.01.022