Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Fangyu Wang, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Masahiko Nakamura, Hirosbi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiromi Yamashita, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticle

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Abstract

Background/Aims: Reactive oxygen species has been implicated in the development of gastric cancer. NADPH oxidase, a major source of superoxide generation play a critical rote in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of gastric cancer, gastric ulcer and duodenal ulcer in a Japanese population. Materials and Method: 376 gastric cancer patients and 436 cancer-free subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the non-cancer subjects, the p22PHOX genotype distribution was 365CC (83.7%), 63CT (15.4%), and 4TT (0.9%). Meanwhile, the p22PHOX genotype distribution in gastric cancer was 311CC (82.7%), 63CT (16.8%), and 2TT (0.5%). There was no significant difference between two groups in the distribution of T carrier frequency (OR=1.04, 95 % CI=0.71-1.53). No association was also observed between p22PHOX genotypes and Lauren's classification, tumor stage and anatomical locations. Conclusion: It appears that the C242T polymorphism of p22PHOX is not associated with the incidence of gastric cancer in the Japanese population.

Original languageEnglish
Pages (from-to)2273-2276
Number of pages4
JournalHepato-Gastroenterology
Volume55
Issue number88
Publication statusPublished - 01-11-2008

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NADPH Oxidase
Stomach Neoplasms
Japan
Incidence
Genotype
Pylorus
Stomach Ulcer
Duodenal Ulcer
Superoxides
Restriction Fragment Length Polymorphisms
Population
Reactive Oxygen Species
Neoplasms
Stomach
Inflammation
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Arisawa, T., Shibata, T., Nakamura, M., Wang, F., Yoshioka, D., ... Hirata, I. (2008). Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan. Hepato-Gastroenterology, 55(88), 2273-2276.
Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Wang, Fangyu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Nakamura, Masahiko ; Fujita, Hirosbi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Makoto ; Yamashita, Hiromi ; Nakano, Hiroshi ; Hirata, Ichiro. / Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 88. pp. 2273-2276.
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title = "Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan",
abstract = "Background/Aims: Reactive oxygen species has been implicated in the development of gastric cancer. NADPH oxidase, a major source of superoxide generation play a critical rote in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of gastric cancer, gastric ulcer and duodenal ulcer in a Japanese population. Materials and Method: 376 gastric cancer patients and 436 cancer-free subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the non-cancer subjects, the p22PHOX genotype distribution was 365CC (83.7{\%}), 63CT (15.4{\%}), and 4TT (0.9{\%}). Meanwhile, the p22PHOX genotype distribution in gastric cancer was 311CC (82.7{\%}), 63CT (16.8{\%}), and 2TT (0.5{\%}). There was no significant difference between two groups in the distribution of T carrier frequency (OR=1.04, 95 {\%} CI=0.71-1.53). No association was also observed between p22PHOX genotypes and Lauren's classification, tumor stage and anatomical locations. Conclusion: It appears that the C242T polymorphism of p22PHOX is not associated with the incidence of gastric cancer in the Japanese population.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Fangyu Wang and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Masahiko Nakamura and Hirosbi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Makoto Watanabe and Hiromi Yamashita and Hiroshi Nakano and Ichiro Hirata",
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Tahara, T, Arisawa, T, Shibata, T, Nakamura, M, Wang, F, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Nakamura, M, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, M, Yamashita, H, Nakano, H & Hirata, I 2008, 'Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan', Hepato-Gastroenterology, vol. 55, no. 88, pp. 2273-2276.

Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Nakamura, Masakatsu; Wang, Fangyu; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Nakamura, Masahiko; Fujita, Hirosbi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Makoto; Yamashita, Hiromi; Nakano, Hiroshi; Hirata, Ichiro.

In: Hepato-Gastroenterology, Vol. 55, No. 88, 01.11.2008, p. 2273-2276.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Wang, Fangyu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Nakamura, Masahiko

AU - Fujita, Hirosbi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Yamashita, Hiromi

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background/Aims: Reactive oxygen species has been implicated in the development of gastric cancer. NADPH oxidase, a major source of superoxide generation play a critical rote in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of gastric cancer, gastric ulcer and duodenal ulcer in a Japanese population. Materials and Method: 376 gastric cancer patients and 436 cancer-free subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the non-cancer subjects, the p22PHOX genotype distribution was 365CC (83.7%), 63CT (15.4%), and 4TT (0.9%). Meanwhile, the p22PHOX genotype distribution in gastric cancer was 311CC (82.7%), 63CT (16.8%), and 2TT (0.5%). There was no significant difference between two groups in the distribution of T carrier frequency (OR=1.04, 95 % CI=0.71-1.53). No association was also observed between p22PHOX genotypes and Lauren's classification, tumor stage and anatomical locations. Conclusion: It appears that the C242T polymorphism of p22PHOX is not associated with the incidence of gastric cancer in the Japanese population.

AB - Background/Aims: Reactive oxygen species has been implicated in the development of gastric cancer. NADPH oxidase, a major source of superoxide generation play a critical rote in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of gastric cancer, gastric ulcer and duodenal ulcer in a Japanese population. Materials and Method: 376 gastric cancer patients and 436 cancer-free subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the non-cancer subjects, the p22PHOX genotype distribution was 365CC (83.7%), 63CT (15.4%), and 4TT (0.9%). Meanwhile, the p22PHOX genotype distribution in gastric cancer was 311CC (82.7%), 63CT (16.8%), and 2TT (0.5%). There was no significant difference between two groups in the distribution of T carrier frequency (OR=1.04, 95 % CI=0.71-1.53). No association was also observed between p22PHOX genotypes and Lauren's classification, tumor stage and anatomical locations. Conclusion: It appears that the C242T polymorphism of p22PHOX is not associated with the incidence of gastric cancer in the Japanese population.

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Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Yoshioka D et al. Genetic variant of the p22PH0X component of NADPH oxidase C242T and the incidence of gastric cancer in Japan. Hepato-Gastroenterology. 2008 Nov 1;55(88):2273-2276.