Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation

Kazunao Kondo, Yasuhiro Suzuki, Yasuhiko Ikeda, Kazuo Umemura

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Diet can be the most important factor that influences risks for cardiovascular diseases. Genistein included in soy is one candidate that may benefit the cardiovascular system. Here, we investigated the inhibitory effects of genistein on thrombotic vessel occlusion in the mouse femoral artery using a photochemical reaction, and in vitro platelet aggregation in whole blood measured by single platelet counting. Genistein (10 mg/kg), intravenously administered 10 min before the rose bengal injection, significantly prolonged the thrombotic occlusion time from 6.1±0.4 to 8.4±0.8 min (P<0.05). Genistein at doses higher than 30 μM significantly (P<0.01) inhibited in vitro platelet aggregation induced by collagen (1 and 3 μg/ml). When 10 mg/kg genistein was intravenously administered, ex vivo platelet aggregation induced by collagen (1 and 3 μg/ml) was significantly suppressed (P<0.01). In conclusion, genistein prevented in vivo thrombogenesis and suppressed in vitro platelet aggregation. These results suggest that dietary supplementation of soy may prevent the progression of thrombosis and atherosclerosis.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalEuropean Journal of Pharmacology
Volume455
Issue number1
DOIs
Publication statusPublished - 22-11-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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