Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung

Anne E. Mattingly; Yohei Doi; Christian Melander

doi:10.1128/mra.00558-25

Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung

Anne E. Mattingly
, Yohei Doi
, Christian Melander

Research output: Contribution to journal › Article › peer-review

Abstract

The genomes of two highly colistin-resistant strains of Pseudomonas aeruginosa (MICs ≥ 1,024 mg/mL) isolated from cystic fibrosis lung infections were sequenced and analyzed. Genes associated with colistin resistance (pmrAB, phoPQ) showed unique mutations compared to other strains with similar resistance levels.

Original language	English
Journal	Microbiology Resource Announcements
Volume	14
Issue number	12
DOIs	https://doi.org/10.1128/mra.00558-25
Publication status	Published - 12-2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

Access to Document

10.1128/mra.00558-25

Cite this

@article{da617b676a5841228869cda2e4a3721d,

title = "Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung",

abstract = "The genomes of two highly colistin-resistant strains of Pseudomonas aeruginosa (MICs ≥ 1,024 mg/mL) isolated from cystic fibrosis lung infections were sequenced and analyzed. Genes associated with colistin resistance (pmrAB, phoPQ) showed unique mutations compared to other strains with similar resistance levels.",

keywords = "Pseudomonas aeruginosa, antibiotic resistance, colistin, cystic fibrosis",

author = "Mattingly, \{Anne E.\} and Yohei Doi and Christian Melander",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Mattingly et al.",

year = "2025",

month = dec,

doi = "10.1128/mra.00558-25",

language = "English",

volume = "14",

journal = "Microbiology Resource Announcements",

issn = "2169-8287",

publisher = "American Society for Microbiology",

number = "12",

}

TY - JOUR

T1 - Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung

AU - Mattingly, Anne E.

AU - Doi, Yohei

AU - Melander, Christian

PY - 2025/12

Y1 - 2025/12

N2 - The genomes of two highly colistin-resistant strains of Pseudomonas aeruginosa (MICs ≥ 1,024 mg/mL) isolated from cystic fibrosis lung infections were sequenced and analyzed. Genes associated with colistin resistance (pmrAB, phoPQ) showed unique mutations compared to other strains with similar resistance levels.

AB - The genomes of two highly colistin-resistant strains of Pseudomonas aeruginosa (MICs ≥ 1,024 mg/mL) isolated from cystic fibrosis lung infections were sequenced and analyzed. Genes associated with colistin resistance (pmrAB, phoPQ) showed unique mutations compared to other strains with similar resistance levels.

KW - Pseudomonas aeruginosa

KW - antibiotic resistance

KW - colistin

KW - cystic fibrosis

UR - https://www.scopus.com/pages/publications/105024800571

UR - https://www.scopus.com/pages/publications/105024800571#tab=citedBy

U2 - 10.1128/mra.00558-25

DO - 10.1128/mra.00558-25

M3 - Article

AN - SCOPUS:105024800571

SN - 2169-8287

VL - 14

JO - Microbiology Resource Announcements

JF - Microbiology Resource Announcements

IS - 12

ER -

Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this