Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

Qiuyin Cai, Ben Zhang, Hyuna Sung, Siew Kee Low, Sun Seog Kweon, Wei Lu, Jiajun Shi, Jirong Long, Wanqing Wen, Ji Yeob Choi, Dong Young Noh, Chen Yang Shen, Keitaro Matsuo, Soo Hwang Teo, Mi Kyung Kim, Ui Soon Khoo, Motoki Iwasaki, Mikael Hartman, Atsushi Takahashi, Kyota AshikawaKoichi Matsuda, Min Ho Shin, Min Ho Park, Ying Zheng, Yong Bing Xiang, Bu Tian Ji, Sue K. Park, Pei Ei Wu, Chia Ni Hsiung, Hidemi Ito, Yoshio Kasuga, Peter Kang, Shivaani Mariapun, Sei Hyun Ahn, Han Sung Kang, Kelvin Y.K. Chan, Ellen P.S. Man, Hiroji Iwata, Shoichiro Tsugane, Hui Miao, Jiemin Liao, Yusuke Nakamura, Michiaki Kubo, Ryan J. Delahanty, Yanfeng Zhang, Bingshan Li, Chun Li, Yu Tang Gao, Xiao Ou Shu, Daehee Kang, Wei Zheng

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P = 8.82 × 10-9), rs10474352 at 5q14.3 (near the ARRDC3 gene; P = 1.67 × 10-9) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P = 4.25 × 10-8). We replicated these associations in 16,003 cases and 41,335 controls of European ancestry (P = 0.030, 0.004 and 0.010, respectively). Data from the ENCODE Project suggest that variants rs4951011 and rs10474352 might be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer.

Original languageEnglish
Pages (from-to)886-890
Number of pages5
JournalNature Genetics
Volume46
Issue number8
DOIs
Publication statusPublished - 08-2014

All Science Journal Classification (ASJC) codes

  • Genetics

Fingerprint Dive into the research topics of 'Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1'. Together they form a unique fingerprint.

Cite this