TY - JOUR
T1 - Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population
AU - Otsuka, Ikuo
AU - Akiyama, Masato
AU - Shirakawa, Osamu
AU - Okazaki, Satoshi
AU - Momozawa, Yukihide
AU - Kamatani, Yoichiro
AU - Izumi, Takeshi
AU - Numata, Shusuke
AU - Takahashi, Motonori
AU - Boku, Shuken
AU - Sora, Ichiro
AU - Yamamoto, Ken
AU - Ueno, Yasuhiro
AU - Toda, Tatsushi
AU - Kubo, Michiaki
AU - Hishimoto, Akitoyo
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (Pbest = 2.7 × 10−13) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.
AB - Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35–48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (Pbest = 2.7 × 10−13) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.
UR - http://www.scopus.com/inward/record.url?scp=85073313471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073313471&partnerID=8YFLogxK
U2 - 10.1038/s41386-019-0506-5
DO - 10.1038/s41386-019-0506-5
M3 - Article
C2 - 31476763
AN - SCOPUS:85073313471
SN - 0893-133X
VL - 44
SP - 2119
EP - 2124
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 12
ER -