Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Minako Imamura, Atsushi Takahashi, Toshimasa Yamauchi, Kazuo Hara, Kazuki Yasuda, Niels Grarup, Wei Zhao, Xu Wang, Alicia Huerta-Chagoya, Cheng Hu, Sanghoon Moon, Jirong Long, Soo Heon Kwak, Asif Rasheed, Richa Saxena, Ronald C.W. Ma, Yukinori Okada, Minoru Iwata, Jun Hosoe, Nobuhiro Shojima & 43 others Minaka Iwasaki, Hayato Fujita, Ken Suzuki, John Danesh, Torben Jørgensen, Marit E. Jørgensen, Daniel R. Witte, Ivan Brandslund, Cramer Christensen, Torben Hansen, Josep M. Mercader, Jason Flannick, Hortensia Moreno-Macías, Noël P. Burtt, Rong Zhang, Young Jin Kim, Wei Zheng, Jai Rup Singh, Claudia H.T. Tam, Hiroshi Hirose, Hiroshi Maegawa, Chikako Ito, Kohei Kaku, Hirotaka Watada, Yasushi Tanaka, Kazuyuki Tobe, Ryuzo Kawamori, Michiaki Kubo, Yoon Shin Cho, Juliana C.N. Chan, Dharambir Sanghera, Philippe Frossard, Kyong Soo Park, Xiao Ou Shu, Bong Jo Kim, Jose C. Florez, Teresa Tusié-Luna, Weiping Jia, E. Shyong Tai, Oluf Pedersen, Danish Saleheen, Shiro Maeda, Takashi Kadowaki

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Abstract

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

Original languageEnglish
Article number10531
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 28-01-2016

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genome
Genome-Wide Association Study
loci
Medical problems
Type 2 Diabetes Mellitus
Genes
Population
magnetic permeability
Meta-Analysis
Genome
expansion

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., ... Kadowaki, T. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications, 7, [10531]. https://doi.org/10.1038/ncomms10531
Imamura, Minako ; Takahashi, Atsushi ; Yamauchi, Toshimasa ; Hara, Kazuo ; Yasuda, Kazuki ; Grarup, Niels ; Zhao, Wei ; Wang, Xu ; Huerta-Chagoya, Alicia ; Hu, Cheng ; Moon, Sanghoon ; Long, Jirong ; Kwak, Soo Heon ; Rasheed, Asif ; Saxena, Richa ; Ma, Ronald C.W. ; Okada, Yukinori ; Iwata, Minoru ; Hosoe, Jun ; Shojima, Nobuhiro ; Iwasaki, Minaka ; Fujita, Hayato ; Suzuki, Ken ; Danesh, John ; Jørgensen, Torben ; Jørgensen, Marit E. ; Witte, Daniel R. ; Brandslund, Ivan ; Christensen, Cramer ; Hansen, Torben ; Mercader, Josep M. ; Flannick, Jason ; Moreno-Macías, Hortensia ; Burtt, Noël P. ; Zhang, Rong ; Kim, Young Jin ; Zheng, Wei ; Singh, Jai Rup ; Tam, Claudia H.T. ; Hirose, Hiroshi ; Maegawa, Hiroshi ; Ito, Chikako ; Kaku, Kohei ; Watada, Hirotaka ; Tanaka, Yasushi ; Tobe, Kazuyuki ; Kawamori, Ryuzo ; Kubo, Michiaki ; Cho, Yoon Shin ; Chan, Juliana C.N. ; Sanghera, Dharambir ; Frossard, Philippe ; Park, Kyong Soo ; Shu, Xiao Ou ; Kim, Bong Jo ; Florez, Jose C. ; Tusié-Luna, Teresa ; Jia, Weiping ; Tai, E. Shyong ; Pedersen, Oluf ; Saleheen, Danish ; Maeda, Shiro ; Kadowaki, Takashi. / Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. In: Nature Communications. 2016 ; Vol. 7.
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abstract = "Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.",
author = "Minako Imamura and Atsushi Takahashi and Toshimasa Yamauchi and Kazuo Hara and Kazuki Yasuda and Niels Grarup and Wei Zhao and Xu Wang and Alicia Huerta-Chagoya and Cheng Hu and Sanghoon Moon and Jirong Long and Kwak, {Soo Heon} and Asif Rasheed and Richa Saxena and Ma, {Ronald C.W.} and Yukinori Okada and Minoru Iwata and Jun Hosoe and Nobuhiro Shojima and Minaka Iwasaki and Hayato Fujita and Ken Suzuki and John Danesh and Torben J{\o}rgensen and J{\o}rgensen, {Marit E.} and Witte, {Daniel R.} and Ivan Brandslund and Cramer Christensen and Torben Hansen and Mercader, {Josep M.} and Jason Flannick and Hortensia Moreno-Mac{\'i}as and Burtt, {No{\"e}l P.} and Rong Zhang and Kim, {Young Jin} and Wei Zheng and Singh, {Jai Rup} and Tam, {Claudia H.T.} and Hiroshi Hirose and Hiroshi Maegawa and Chikako Ito and Kohei Kaku and Hirotaka Watada and Yasushi Tanaka and Kazuyuki Tobe and Ryuzo Kawamori and Michiaki Kubo and Cho, {Yoon Shin} and Chan, {Juliana C.N.} and Dharambir Sanghera and Philippe Frossard and Park, {Kyong Soo} and Shu, {Xiao Ou} and Kim, {Bong Jo} and Florez, {Jose C.} and Teresa Tusi{\'e}-Luna and Weiping Jia and Tai, {E. Shyong} and Oluf Pedersen and Danish Saleheen and Shiro Maeda and Takashi Kadowaki",
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Imamura, M, Takahashi, A, Yamauchi, T, Hara, K, Yasuda, K, Grarup, N, Zhao, W, Wang, X, Huerta-Chagoya, A, Hu, C, Moon, S, Long, J, Kwak, SH, Rasheed, A, Saxena, R, Ma, RCW, Okada, Y, Iwata, M, Hosoe, J, Shojima, N, Iwasaki, M, Fujita, H, Suzuki, K, Danesh, J, Jørgensen, T, Jørgensen, ME, Witte, DR, Brandslund, I, Christensen, C, Hansen, T, Mercader, JM, Flannick, J, Moreno-Macías, H, Burtt, NP, Zhang, R, Kim, YJ, Zheng, W, Singh, JR, Tam, CHT, Hirose, H, Maegawa, H, Ito, C, Kaku, K, Watada, H, Tanaka, Y, Tobe, K, Kawamori, R, Kubo, M, Cho, YS, Chan, JCN, Sanghera, D, Frossard, P, Park, KS, Shu, XO, Kim, BJ, Florez, JC, Tusié-Luna, T, Jia, W, Tai, ES, Pedersen, O, Saleheen, D, Maeda, S & Kadowaki, T 2016, 'Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes', Nature Communications, vol. 7, 10531. https://doi.org/10.1038/ncomms10531

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. / Imamura, Minako; Takahashi, Atsushi; Yamauchi, Toshimasa; Hara, Kazuo; Yasuda, Kazuki; Grarup, Niels; Zhao, Wei; Wang, Xu; Huerta-Chagoya, Alicia; Hu, Cheng; Moon, Sanghoon; Long, Jirong; Kwak, Soo Heon; Rasheed, Asif; Saxena, Richa; Ma, Ronald C.W.; Okada, Yukinori; Iwata, Minoru; Hosoe, Jun; Shojima, Nobuhiro; Iwasaki, Minaka; Fujita, Hayato; Suzuki, Ken; Danesh, John; Jørgensen, Torben; Jørgensen, Marit E.; Witte, Daniel R.; Brandslund, Ivan; Christensen, Cramer; Hansen, Torben; Mercader, Josep M.; Flannick, Jason; Moreno-Macías, Hortensia; Burtt, Noël P.; Zhang, Rong; Kim, Young Jin; Zheng, Wei; Singh, Jai Rup; Tam, Claudia H.T.; Hirose, Hiroshi; Maegawa, Hiroshi; Ito, Chikako; Kaku, Kohei; Watada, Hirotaka; Tanaka, Yasushi; Tobe, Kazuyuki; Kawamori, Ryuzo; Kubo, Michiaki; Cho, Yoon Shin; Chan, Juliana C.N.; Sanghera, Dharambir; Frossard, Philippe; Park, Kyong Soo; Shu, Xiao Ou; Kim, Bong Jo; Florez, Jose C.; Tusié-Luna, Teresa; Jia, Weiping; Tai, E. Shyong; Pedersen, Oluf; Saleheen, Danish; Maeda, Shiro; Kadowaki, Takashi.

In: Nature Communications, Vol. 7, 10531, 28.01.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

AU - Imamura, Minako

AU - Takahashi, Atsushi

AU - Yamauchi, Toshimasa

AU - Hara, Kazuo

AU - Yasuda, Kazuki

AU - Grarup, Niels

AU - Zhao, Wei

AU - Wang, Xu

AU - Huerta-Chagoya, Alicia

AU - Hu, Cheng

AU - Moon, Sanghoon

AU - Long, Jirong

AU - Kwak, Soo Heon

AU - Rasheed, Asif

AU - Saxena, Richa

AU - Ma, Ronald C.W.

AU - Okada, Yukinori

AU - Iwata, Minoru

AU - Hosoe, Jun

AU - Shojima, Nobuhiro

AU - Iwasaki, Minaka

AU - Fujita, Hayato

AU - Suzuki, Ken

AU - Danesh, John

AU - Jørgensen, Torben

AU - Jørgensen, Marit E.

AU - Witte, Daniel R.

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Hansen, Torben

AU - Mercader, Josep M.

AU - Flannick, Jason

AU - Moreno-Macías, Hortensia

AU - Burtt, Noël P.

AU - Zhang, Rong

AU - Kim, Young Jin

AU - Zheng, Wei

AU - Singh, Jai Rup

AU - Tam, Claudia H.T.

AU - Hirose, Hiroshi

AU - Maegawa, Hiroshi

AU - Ito, Chikako

AU - Kaku, Kohei

AU - Watada, Hirotaka

AU - Tanaka, Yasushi

AU - Tobe, Kazuyuki

AU - Kawamori, Ryuzo

AU - Kubo, Michiaki

AU - Cho, Yoon Shin

AU - Chan, Juliana C.N.

AU - Sanghera, Dharambir

AU - Frossard, Philippe

AU - Park, Kyong Soo

AU - Shu, Xiao Ou

AU - Kim, Bong Jo

AU - Florez, Jose C.

AU - Tusié-Luna, Teresa

AU - Jia, Weiping

AU - Tai, E. Shyong

AU - Pedersen, Oluf

AU - Saleheen, Danish

AU - Maeda, Shiro

AU - Kadowaki, Takashi

PY - 2016/1/28

Y1 - 2016/1/28

N2 - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

AB - Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

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DO - 10.1038/ncomms10531

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JO - Nature Communications

JF - Nature Communications

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