Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

Original languageEnglish
Pages (from-to)52-63
Number of pages12
JournalPsychiatry and clinical neurosciences
Volume72
Issue number2
DOIs
Publication statusPublished - 01-02-2018

Fingerprint

Genome-Wide Association Study
Bipolar Disorder
Single Nucleotide Polymorphism
Disease Susceptibility
Genes
Psychiatry
Meta-Analysis
Molecular Biology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{2212b9eb468541d286e0df0262523aba,
title = "Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications",
abstract = "Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.",
author = "Masashi Ikeda and Takeo Saito and Kenji Kondo and Nakao Iwata",
year = "2018",
month = "2",
day = "1",
doi = "10.1111/pcn.12611",
language = "English",
volume = "72",
pages = "52--63",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Genome-wide association studies of bipolar disorder

T2 - A systematic review of recent findings and their clinical implications

AU - Ikeda, Masashi

AU - Saito, Takeo

AU - Kondo, Kenji

AU - Iwata, Nakao

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

AB - Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

UR - http://www.scopus.com/inward/record.url?scp=85042071751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042071751&partnerID=8YFLogxK

U2 - 10.1111/pcn.12611

DO - 10.1111/pcn.12611

M3 - Review article

C2 - 29057581

AN - SCOPUS:85042071751

VL - 72

SP - 52

EP - 63

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

SN - 1323-1316

IS - 2

ER -