Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Masashi Ikeda; Takeo Saito; Kenji Kondo; Nakao Iwata

doi:10.1111/pcn.12611

Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Masashi Ikeda, Takeo Saito, Kenji Kondo, Nakao Iwata

visiting faculty

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

Abstract

Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

Original language	English
Pages (from-to)	52-63
Number of pages	12
Journal	Psychiatry and clinical neurosciences
Volume	72
Issue number	2
DOIs	https://doi.org/10.1111/pcn.12611
Publication status	Published - 02-2018

All Science Journal Classification (ASJC) codes

General Neuroscience
Neurology
Clinical Neurology
Psychiatry and Mental health

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10.1111/pcn.12611

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title = "Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications",

abstract = "Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.",

author = "Masashi Ikeda and Takeo Saito and Kenji Kondo and Nakao Iwata",

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AU - Iwata, Nakao

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AB - Recent advances in molecular genetics have enabled assessments of the associations among genetic variants (e.g., single-nucleotide polymorphisms) and susceptibility for complex diseases, including psychiatric disorders. Specifically, genome-wide association studies (GWAS), meta-analyses of the GWAS summary statistics, and mega-analyses (which use raw data, not summary statistics) of GWAS have provided revolutionary results and have identified numerous susceptibility genes or single-nucleotide polymorphisms. By using several tens of thousands of subjects, >40 genes have been identified as being associated with susceptibility for bipolar disorder so far. The purpose of this systematic review was to summarize the recent findings of bipolar disorder GWAS and discuss their clinical implications.

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Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

Abstract

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