Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population

Koichi Matsuda; Atsushi Takahashi; Candace D. Middlebrooks; Wataru Obara; Yasutomo Nasu; Keiji Inoue; Kenji Tamura; Ichiro Yamasaki; Yoshio Naya; Chizu Tanikawa; Ri Cui; Jonine D. Figueroa; Debra T. Silverman; Nathaniel Rothman; Mikio Namiki; Yoshihiko Tomita; Hiroyuki Nishiyama; Kenjiro Kohri; Takashi Deguchi; Masayuki Nakagawa; Masayoshi Yokoyama; Tsuneharu Miki; Hiromi Kumon; Tomoaki Fujioka; Ludmila Prokunina-Olsson; Michiaki Kubo; Yusuke Nakamura; Taro Shuin

doi:10.1093/hmg/ddu512

Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population

Koichi Matsuda, Atsushi Takahashi, Candace D. Middlebrooks, Wataru Obara, Yasutomo Nasu, Keiji Inoue, Kenji Tamura, Ichiro Yamasaki, Yoshio Naya, Chizu Tanikawa, Ri Cui, Jonine D. Figueroa, Debra T. Silverman, Nathaniel Rothman, Mikio Namiki, Yoshihiko Tomita, Hiroyuki Nishiyama, Kenjiro Kohri, Takashi Deguchi, Masayuki NakagawaMasayoshi Yokoyama, Tsuneharu Miki, Hiromi Kumon, Tomoaki Fujioka, Ludmila Prokunina-Olsson, Michiaki Kubo, Yusuke Nakamura, Taro Shuin

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Abstract

Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10^-9. Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r² = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmed the association of previously reported loci, namely SLC14A1, APOBEC3A, PSCA and MYC, with bladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer.

Original language	English
Pages (from-to)	1177-1184
Number of pages	8
Journal	Human molecular genetics
Volume	24
Issue number	4
DOIs	https://doi.org/10.1093/hmg/ddu512
Publication status	Published - 15-02-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

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Matsuda, K., Takahashi, A., Middlebrooks, C. D., Obara, W., Nasu, Y., Inoue, K., Tamura, K., Yamasaki, I., Naya, Y., Tanikawa, C., Cui, R., Figueroa, J. D., Silverman, D. T., Rothman, N., Namiki, M., Tomita, Y., Nishiyama, H., Kohri, K., Deguchi, T., ... Shuin, T. (2015). Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population. Human molecular genetics, 24(4), 1177-1184. https://doi.org/10.1093/hmg/ddu512

@article{819225f49628436698a76c71b4528338,

title = "Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population",

abstract = "Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10-9. Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r2 = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmed the association of previously reported loci, namely SLC14A1, APOBEC3A, PSCA and MYC, with bladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer.",

author = "Koichi Matsuda and Atsushi Takahashi and Middlebrooks, {Candace D.} and Wataru Obara and Yasutomo Nasu and Keiji Inoue and Kenji Tamura and Ichiro Yamasaki and Yoshio Naya and Chizu Tanikawa and Ri Cui and Figueroa, {Jonine D.} and Silverman, {Debra T.} and Nathaniel Rothman and Mikio Namiki and Yoshihiko Tomita and Hiroyuki Nishiyama and Kenjiro Kohri and Takashi Deguchi and Masayuki Nakagawa and Masayoshi Yokoyama and Tsuneharu Miki and Hiromi Kumon and Tomoaki Fujioka and Ludmila Prokunina-Olsson and Michiaki Kubo and Yusuke Nakamura and Taro Shuin",

year = "2015",

month = feb,

day = "15",

doi = "10.1093/hmg/ddu512",

language = "English",

volume = "24",

pages = "1177--1184",

journal = "Human molecular genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

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Matsuda, K, Takahashi, A, Middlebrooks, CD, Obara, W, Nasu, Y, Inoue, K, Tamura, K, Yamasaki, I, Naya, Y, Tanikawa, C, Cui, R, Figueroa, JD, Silverman, DT, Rothman, N, Namiki, M, Tomita, Y, Nishiyama, H, Kohri, K, Deguchi, T, Nakagawa, M, Yokoyama, M, Miki, T, Kumon, H, Fujioka, T, Prokunina-Olsson, L, Kubo, M, Nakamura, Y & Shuin, T 2015, 'Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population', Human molecular genetics, vol. 24, no. 4, pp. 1177-1184. https://doi.org/10.1093/hmg/ddu512

TY - JOUR

T1 - Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population

AU - Matsuda, Koichi

AU - Takahashi, Atsushi

AU - Middlebrooks, Candace D.

AU - Obara, Wataru

AU - Nasu, Yasutomo

AU - Inoue, Keiji

AU - Tamura, Kenji

AU - Yamasaki, Ichiro

AU - Naya, Yoshio

AU - Tanikawa, Chizu

AU - Cui, Ri

AU - Figueroa, Jonine D.

AU - Silverman, Debra T.

AU - Rothman, Nathaniel

AU - Namiki, Mikio

AU - Tomita, Yoshihiko

AU - Nishiyama, Hiroyuki

AU - Kohri, Kenjiro

AU - Deguchi, Takashi

AU - Nakagawa, Masayuki

AU - Yokoyama, Masayoshi

AU - Miki, Tsuneharu

AU - Kumon, Hiromi

AU - Fujioka, Tomoaki

AU - Prokunina-Olsson, Ludmila

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Shuin, Taro

PY - 2015/2/15

Y1 - 2015/2/15

N2 - Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10-9. Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r2 = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmed the association of previously reported loci, namely SLC14A1, APOBEC3A, PSCA and MYC, with bladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer.

AB - Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10-9. Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r2 = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmed the association of previously reported loci, namely SLC14A1, APOBEC3A, PSCA and MYC, with bladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer.

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U2 - 10.1093/hmg/ddu512

DO - 10.1093/hmg/ddu512

M3 - Article

C2 - 25281661

AN - SCOPUS:84922455874

SN - 0964-6906

VL - 24

SP - 1177

EP - 1184

JO - Human molecular genetics

JF - Human molecular genetics

IS - 4

ER -

Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population

Abstract

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