Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Tsuyoshi Hachiya, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Naoko Minegishi, Shoichiro Tsugane, Masayuki YamamotoMichiaki Kubo, Yoichiro Kamatani

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19+ cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10-5, rg = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.

Original languageEnglish
Pages (from-to)1458-1467
Number of pages10
JournalNature Genetics
Volume49
Issue number10
DOIs
Publication statusPublished - 01-10-2017

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Genome-Wide Association Study
Body Mass Index
Obesity
Population
Lymphocyte Count
Meta-Analysis
Body Weight
Lymphocytes
Health

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Akiyama, M., Okada, Y., Kanai, M., Takahashi, A., Momozawa, Y., Ikeda, M., ... Kamatani, Y. (2017). Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nature Genetics, 49(10), 1458-1467. https://doi.org/10.1038/ng.3951
Akiyama, Masato ; Okada, Yukinori ; Kanai, Masahiro ; Takahashi, Atsushi ; Momozawa, Yukihide ; Ikeda, Masashi ; Iwata, Nakao ; Ikegawa, Shiro ; Hirata, Makoto ; Matsuda, Koichi ; Iwasaki, Motoki ; Yamaji, Taiki ; Sawada, Norie ; Hachiya, Tsuyoshi ; Tanno, Kozo ; Shimizu, Atsushi ; Hozawa, Atsushi ; Minegishi, Naoko ; Tsugane, Shoichiro ; Yamamoto, Masayuki ; Kubo, Michiaki ; Kamatani, Yoichiro. / Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. In: Nature Genetics. 2017 ; Vol. 49, No. 10. pp. 1458-1467.
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abstract = "Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19+ cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10-5, rg = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.",
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Akiyama, M, Okada, Y, Kanai, M, Takahashi, A, Momozawa, Y, Ikeda, M, Iwata, N, Ikegawa, S, Hirata, M, Matsuda, K, Iwasaki, M, Yamaji, T, Sawada, N, Hachiya, T, Tanno, K, Shimizu, A, Hozawa, A, Minegishi, N, Tsugane, S, Yamamoto, M, Kubo, M & Kamatani, Y 2017, 'Genome-wide association study identifies 112 new loci for body mass index in the Japanese population', Nature Genetics, vol. 49, no. 10, pp. 1458-1467. https://doi.org/10.1038/ng.3951

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. / Akiyama, Masato; Okada, Yukinori; Kanai, Masahiro; Takahashi, Atsushi; Momozawa, Yukihide; Ikeda, Masashi; Iwata, Nakao; Ikegawa, Shiro; Hirata, Makoto; Matsuda, Koichi; Iwasaki, Motoki; Yamaji, Taiki; Sawada, Norie; Hachiya, Tsuyoshi; Tanno, Kozo; Shimizu, Atsushi; Hozawa, Atsushi; Minegishi, Naoko; Tsugane, Shoichiro; Yamamoto, Masayuki; Kubo, Michiaki; Kamatani, Yoichiro.

In: Nature Genetics, Vol. 49, No. 10, 01.10.2017, p. 1458-1467.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

AU - Akiyama, Masato

AU - Okada, Yukinori

AU - Kanai, Masahiro

AU - Takahashi, Atsushi

AU - Momozawa, Yukihide

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Ikegawa, Shiro

AU - Hirata, Makoto

AU - Matsuda, Koichi

AU - Iwasaki, Motoki

AU - Yamaji, Taiki

AU - Sawada, Norie

AU - Hachiya, Tsuyoshi

AU - Tanno, Kozo

AU - Shimizu, Atsushi

AU - Hozawa, Atsushi

AU - Minegishi, Naoko

AU - Tsugane, Shoichiro

AU - Yamamoto, Masayuki

AU - Kubo, Michiaki

AU - Kamatani, Yoichiro

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10-8), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19+ cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10-5, rg = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.

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