Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population

Hisatsugu Koshimizu, Shun Nogawa, Shinya Asano, Masashi Ikeda, Nakao Iwata, Shoko Takahashi, Kenji Saito, Tsuyoshi Miyakawa

Research output: Contribution to journalArticle

Abstract

Major depressive disorder (MDD) is a common and disabling psychiatric disorder. A recent mega analysis of genome-wide association studies (GWASs) identified 44 loci associated with MDD, though most of the genetic etiologies of the MDD/psychological distress remain unclear. To further understand the genetic basis of MDD/psychological distress, we conducted a GWAS in East Asia with more than 10,000 participants of Japanese ancestry who had enrolled in a direct-to-consumer genetic test. After quality control on the genotype data, 10,330 subjects with a total of 8,567,708 imputed SNPs were eligible for the analysis. The participants completed a self-administered questionnaire on their past medical history and health conditions that included the 6-item Kessler screening scale (K6 scale) for psychological distress (cut-off point of 5) and past medical history of MDD, resulting in 3981 subjects assigned to “psychologically distressed group” [cases], and the remaining 6349 subjects were assigned to the “non-psychologically distressed group” [controls]. In this GWAS, we found an association with genome-wide significance at rs6073833 (P = 7.60 × 10 −9 ) in 20q13.12. This is, to the best of our knowledge, the first large-scale GWAS for psychological distress using data from direct-to-consumer (DTC) genetic tests in a population of non-European-ancestry, and the present study thus detected a novel locus significantly associated with psychological distress in the Japanese population.

Original languageEnglish
Article number52
JournalTranslational psychiatry
Volume9
Issue number1
DOIs
Publication statusPublished - 01-12-2019

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Genome-Wide Association Study
Major Depressive Disorder
Psychology
Population
Far East
Quality Control
Single Nucleotide Polymorphism
Psychiatry
Genotype
Genome
Control Groups
Health

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

Cite this

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title = "Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population",
abstract = "Major depressive disorder (MDD) is a common and disabling psychiatric disorder. A recent mega analysis of genome-wide association studies (GWASs) identified 44 loci associated with MDD, though most of the genetic etiologies of the MDD/psychological distress remain unclear. To further understand the genetic basis of MDD/psychological distress, we conducted a GWAS in East Asia with more than 10,000 participants of Japanese ancestry who had enrolled in a direct-to-consumer genetic test. After quality control on the genotype data, 10,330 subjects with a total of 8,567,708 imputed SNPs were eligible for the analysis. The participants completed a self-administered questionnaire on their past medical history and health conditions that included the 6-item Kessler screening scale (K6 scale) for psychological distress (cut-off point of 5) and past medical history of MDD, resulting in 3981 subjects assigned to “psychologically distressed group” [cases], and the remaining 6349 subjects were assigned to the “non-psychologically distressed group” [controls]. In this GWAS, we found an association with genome-wide significance at rs6073833 (P = 7.60 × 10 −9 ) in 20q13.12. This is, to the best of our knowledge, the first large-scale GWAS for psychological distress using data from direct-to-consumer (DTC) genetic tests in a population of non-European-ancestry, and the present study thus detected a novel locus significantly associated with psychological distress in the Japanese population.",
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Genome-wide association study identifies a novel locus associated with psychological distress in the Japanese population. / Koshimizu, Hisatsugu; Nogawa, Shun; Asano, Shinya; Ikeda, Masashi; Iwata, Nakao; Takahashi, Shoko; Saito, Kenji; Miyakawa, Tsuyoshi.

In: Translational psychiatry, Vol. 9, No. 1, 52, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Koshimizu, Hisatsugu

AU - Nogawa, Shun

AU - Asano, Shinya

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Takahashi, Shoko

AU - Saito, Kenji

AU - Miyakawa, Tsuyoshi

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