Abstract
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1222-1226 |
| Number of pages | 5 |
| Journal | Nature Genetics |
| Volume | 44 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 01-11-2012 |
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All Science Journal Classification (ASJC) codes
- Genetics
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Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. / Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Sakashita, Masafumi; Yamada, Takechiyo; Fujieda, Shigeharu; Tanaka, Shota; Doi, Satoru; Miyatake, Akihiko; Enomoto, Tadao; Nishiyama, Chiharu; Nakano, Nobuhiro; Maeda, Keiko; Okumura, Ko; Ogawa, Hideoki; Ikeda, Shigaku; Noguchi, Emiko; Sakamoto, Tohru; Hizawa, Nobuyuki; Ebe, Koji; Saeki, Hidehisa; Sasaki, Takashi; Ebihara, Tamotsu; Amagai, Masayuki; Takeuchi, Satoshi; Furue, Masutaka; Nakamura, Yusuke; Tamari, Mayumi.
In: Nature Genetics, Vol. 44, No. 11, 01.11.2012, p. 1222-1226.Research output: Contribution to journal › Article
TY - JOUR
T1 - Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
AU - Hirota, Tomomitsu
AU - Takahashi, Atsushi
AU - Kubo, Michiaki
AU - Tsunoda, Tatsuhiko
AU - Tomita, Kaori
AU - Sakashita, Masafumi
AU - Yamada, Takechiyo
AU - Fujieda, Shigeharu
AU - Tanaka, Shota
AU - Doi, Satoru
AU - Miyatake, Akihiko
AU - Enomoto, Tadao
AU - Nishiyama, Chiharu
AU - Nakano, Nobuhiro
AU - Maeda, Keiko
AU - Okumura, Ko
AU - Ogawa, Hideoki
AU - Ikeda, Shigaku
AU - Noguchi, Emiko
AU - Sakamoto, Tohru
AU - Hizawa, Nobuyuki
AU - Ebe, Koji
AU - Saeki, Hidehisa
AU - Sasaki, Takashi
AU - Ebihara, Tamotsu
AU - Amagai, Masayuki
AU - Takeuchi, Satoshi
AU - Furue, Masutaka
AU - Nakamura, Yusuke
AU - Tamari, Mayumi
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
AB - Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
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U2 - 10.1038/ng.2438
DO - 10.1038/ng.2438
M3 - Article
VL - 44
SP - 1222
EP - 1226
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -