TY - JOUR
T1 - Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
AU - Hirota, Tomomitsu
AU - Takahashi, Atsushi
AU - Kubo, Michiaki
AU - Tsunoda, Tatsuhiko
AU - Tomita, Kaori
AU - Sakashita, Masafumi
AU - Yamada, Takechiyo
AU - Fujieda, Shigeharu
AU - Tanaka, Shota
AU - Doi, Satoru
AU - Miyatake, Akihiko
AU - Enomoto, Tadao
AU - Nishiyama, Chiharu
AU - Nakano, Nobuhiro
AU - Maeda, Keiko
AU - Okumura, Ko
AU - Ogawa, Hideoki
AU - Ikeda, Shigaku
AU - Noguchi, Emiko
AU - Sakamoto, Tohru
AU - Hizawa, Nobuyuki
AU - Ebe, Koji
AU - Saeki, Hidehisa
AU - Sasaki, Takashi
AU - Ebihara, Tamotsu
AU - Amagai, Masayuki
AU - Takeuchi, Satoshi
AU - Furue, Masutaka
AU - Nakamura, Yusuke
AU - Tamari, Mayumi
N1 - Funding Information:
We thank all the individuals who participated in the study and also thank the collaborating physicians for helping with sample collection. We are grateful to the members of BioBank Japan and the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. We thank M.T. Shimizu, H. Sekiguchi, A.I. Jodo, N. Kawaraichi and the technical staff of the Center for Genomic Medicine for providing technical assistance and K. Barrymore for proofreading this manuscript. This work was conducted as part of the BioBank Japan Project, which is supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. This work was also partly supported by grants from the Ministry of Health, Labour and Welfare, Japan.
PY - 2012/11
Y1 - 2012/11
N2 - Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
AB - Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
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U2 - 10.1038/ng.2438
DO - 10.1038/ng.2438
M3 - Article
C2 - 23042114
AN - SCOPUS:84868195423
VL - 44
SP - 1222
EP - 1226
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -