Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Ryo Takata; Shusuke Akamatsu; Michiaki Kubo; Atsushi Takahashi; Naoya Hosono; Takahisa Kawaguchi; Tatsuhiko Tsunoda; Johji Inazawa; Naoyuki Kamatani; Osamu Ogawa; Tomoaki Fujioka; Yusuke Nakamura; Hidewaki Nakagawa

doi:10.1038/ng.635

Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Ryo Takata, Shusuke Akamatsu, Michiaki Kubo, Atsushi Takahashi, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Johji Inazawa, Naoyuki Kamatani, Osamu Ogawa, Tomoaki Fujioka, Yusuke Nakamura, Hidewaki Nakagawa

Research output: Contribution to journal › Letter › peer-review

248 Citations (Scopus)

Abstract

Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-⁷ and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability P_GC = 3.9 x 10-¹⁸), GPRC6A/RFX6 (P_GC = 1.6 x 10-12), 13q22 (P_GC = 2.8 x 10-⁹), C2orf43 (P_GC = 7.5 x 10-⁸) and FOXP4 (P_GC = 7.6 x 10-⁸). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

Original language	English
Pages (from-to)	751-755
Number of pages	5
Journal	Nature Genetics
Volume	42
Issue number	9
DOIs	https://doi.org/10.1038/ng.635
Publication status	Published - 09-2010
Externally published	Yes

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Genetics

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10.1038/ng.635

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@article{8a52bfe385384ecc84ee58b18fe42e7c,

title = "Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population",

abstract = "Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability PGC = 3.9 x 10-18), GPRC6A/RFX6 (PGC = 1.6 x 10-12), 13q22 (PGC = 2.8 x 10-9), C2orf43 (PGC = 7.5 x 10-8) and FOXP4 (PGC = 7.6 x 10-8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.",

author = "Ryo Takata and Shusuke Akamatsu and Michiaki Kubo and Atsushi Takahashi and Naoya Hosono and Takahisa Kawaguchi and Tatsuhiko Tsunoda and Johji Inazawa and Naoyuki Kamatani and Osamu Ogawa and Tomoaki Fujioka and Yusuke Nakamura and Hidewaki Nakagawa",

year = "2010",

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doi = "10.1038/ng.635",

language = "English",

volume = "42",

pages = "751--755",

journal = "Nature Genetics",

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T1 - Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

AU - Takata, Ryo

AU - Akamatsu, Shusuke

AU - Kubo, Michiaki

AU - Takahashi, Atsushi

AU - Hosono, Naoya

AU - Kawaguchi, Takahisa

AU - Tsunoda, Tatsuhiko

AU - Inazawa, Johji

AU - Kamatani, Naoyuki

AU - Ogawa, Osamu

AU - Fujioka, Tomoaki

AU - Nakamura, Yusuke

AU - Nakagawa, Hidewaki

PY - 2010/9

Y1 - 2010/9

N2 - Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability PGC = 3.9 x 10-18), GPRC6A/RFX6 (PGC = 1.6 x 10-12), 13q22 (PGC = 2.8 x 10-9), C2orf43 (PGC = 7.5 x 10-8) and FOXP4 (PGC = 7.6 x 10-8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

AB - Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability PGC = 3.9 x 10-18), GPRC6A/RFX6 (PGC = 1.6 x 10-12), 13q22 (PGC = 2.8 x 10-9), C2orf43 (PGC = 7.5 x 10-8) and FOXP4 (PGC = 7.6 x 10-8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

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Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Abstract

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