Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Ryo Takata, Shusuke Akamatsu, Michiaki Kubo, Atsushi Takahashi, Naoya Hosono, Takahisa Kawaguchi, Tatsuhiko Tsunoda, Johji Inazawa, Naoyuki Kamatani, Osamu Ogawa, Tomoaki Fujioka, Yusuke Nakamura, Hidewaki Nakagawa

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211 Citations (Scopus)

Abstract

Prostate cancer is one of the most common malignancies in males throughout the world1, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10-7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ -corrected probability PGC = 3.9 x 10-18), GPRC6A/RFX6 (PGC = 1.6 x 10-12), 13q22 (PGC = 2.8 x 10-9), C2orf43 (PGC = 7.5 x 10-8) and FOXP4 (PGC = 7.6 x 10-8). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.

Original languageEnglish
Pages (from-to)751-755
Number of pages5
JournalNature Genetics
Volume42
Issue number9
DOIs
Publication statusPublished - 01-01-2010

All Science Journal Classification (ASJC) codes

  • Genetics

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    Takata, R., Akamatsu, S., Kubo, M., Takahashi, A., Hosono, N., Kawaguchi, T., Tsunoda, T., Inazawa, J., Kamatani, N., Ogawa, O., Fujioka, T., Nakamura, Y., & Nakagawa, H. (2010). Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nature Genetics, 42(9), 751-755. https://doi.org/10.1038/ng.635