Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

Chizu Tanikawa, Yoichiro Kamatani, Osamu Toyoshima, Hiromi Sakamoto, Hidemi Ito, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Nobuo Fuse, Takako Takai-Igarashi, Atsushi Shimizu, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Mariko Naito, Asahi Hishida, Kenji Wakai, Norihiro FurusyoYoshinori Murakami, Yusuke Nakamura, Issei Imoto, Johji Inazawa, Isao Oze, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Hiroshi Hirose, Teruhiko Yoshida, Keitaro Matsuo, Michiaki Kubo, Koichi Matsuda

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36 Citations (Scopus)


Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, herein, we carried out a large-scale genome-wide association study using 6171 cases and 27 178 controls followed by three replication analyses. Analysis using a total of 11 507 cases and 38 904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3.20 × 10−8 with an odds ratio [OR] of 0.905) and 20q11.21 (rs2376549, P = 8.11 × 10−10 with an OR of 1.109). rs6490061 is located at intron 19 of the CUX2 gene, and its expression was suppressed by Helicobacter pylori infection. rs2376549 is included within the gene cluster of DEFB families that encode antibacterial peptides. We also found a significant association of rs7849280 in the ABO gene locus on 9q34.2 (P = 2.64 × 10−13 with an OR of 1.148). CUX2 and ABO expression in gastric mucosal tissues was significantly associated with rs6490061 and rs7849280 (P = 0.0153 and 8.00 × 10−11), respectively. Our findings show the crucial roles of genetic variations in the pathogenesis of gastric cancer.

Original languageEnglish
Pages (from-to)4015-4024
Number of pages10
JournalCancer science
Issue number12
Publication statusPublished - 12-2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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