Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J. LimaCharles G. Irvin, Stephen P. Peters, Blanca E. Himes, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari

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257 Citations (Scopus)


Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87×10 -12), a locus on chromosome 10p14 (P = 1.79 ×-10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 ×10 -13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07× 10 -23), which is close to rs2070600, a SNP previously reported for association with FEV 1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalNature Genetics
Issue number9
Publication statusPublished - 09-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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