Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J. LimaCharles G. Irvin, Stephen P. Peters, Blanca E. Himes, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87×10 -12), a locus on chromosome 10p14 (P = 1.79 ×-10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 ×10 -13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07× 10 -23), which is close to rs2070600, a SNP previously reported for association with FEV 1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalNature Genetics
Volume43
Issue number9
DOIs
Publication statusPublished - 01-09-2011

Fingerprint

Genome-Wide Association Study
Asthma
Chromosomes
Population
Major Histocompatibility Complex
Single Nucleotide Polymorphism
Lung
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Hirota, Tomomitsu ; Takahashi, Atsushi ; Kubo, Michiaki ; Tsunoda, Tatsuhiko ; Tomita, Kaori ; Doi, Satoru ; Fujita, Kimie ; Miyatake, Akihiko ; Enomoto, Tadao ; Miyagawa, Takehiko ; Adachi, Mitsuru ; Tanaka, Hiroshi ; Niimi, Akio ; Matsumoto, Hisako ; Ito, Isao ; Masuko, Hironori ; Sakamoto, Tohru ; Hizawa, Nobuyuki ; Taniguchi, Masami ; Lima, John J. ; Irvin, Charles G. ; Peters, Stephen P. ; Himes, Blanca E. ; Litonjua, Augusto A. ; Tantisira, Kelan G. ; Weiss, Scott T. ; Kamatani, Naoyuki ; Nakamura, Yusuke ; Tamari, Mayumi. / Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. In: Nature Genetics. 2011 ; Vol. 43, No. 9. pp. 893-896.
@article{d2e56a7e4fb84b44a00146ef565625bb,
title = "Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population",
abstract = "Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87×10 -12), a locus on chromosome 10p14 (P = 1.79 ×-10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 ×10 -13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07× 10 -23), which is close to rs2070600, a SNP previously reported for association with FEV 1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.",
author = "Tomomitsu Hirota and Atsushi Takahashi and Michiaki Kubo and Tatsuhiko Tsunoda and Kaori Tomita and Satoru Doi and Kimie Fujita and Akihiko Miyatake and Tadao Enomoto and Takehiko Miyagawa and Mitsuru Adachi and Hiroshi Tanaka and Akio Niimi and Hisako Matsumoto and Isao Ito and Hironori Masuko and Tohru Sakamoto and Nobuyuki Hizawa and Masami Taniguchi and Lima, {John J.} and Irvin, {Charles G.} and Peters, {Stephen P.} and Himes, {Blanca E.} and Litonjua, {Augusto A.} and Tantisira, {Kelan G.} and Weiss, {Scott T.} and Naoyuki Kamatani and Yusuke Nakamura and Mayumi Tamari",
year = "2011",
month = "9",
day = "1",
doi = "10.1038/ng.887",
language = "English",
volume = "43",
pages = "893--896",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",

}

Hirota, T, Takahashi, A, Kubo, M, Tsunoda, T, Tomita, K, Doi, S, Fujita, K, Miyatake, A, Enomoto, T, Miyagawa, T, Adachi, M, Tanaka, H, Niimi, A, Matsumoto, H, Ito, I, Masuko, H, Sakamoto, T, Hizawa, N, Taniguchi, M, Lima, JJ, Irvin, CG, Peters, SP, Himes, BE, Litonjua, AA, Tantisira, KG, Weiss, ST, Kamatani, N, Nakamura, Y & Tamari, M 2011, 'Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population', Nature Genetics, vol. 43, no. 9, pp. 893-896. https://doi.org/10.1038/ng.887

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. / Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Doi, Satoru; Fujita, Kimie; Miyatake, Akihiko; Enomoto, Tadao; Miyagawa, Takehiko; Adachi, Mitsuru; Tanaka, Hiroshi; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Masuko, Hironori; Sakamoto, Tohru; Hizawa, Nobuyuki; Taniguchi, Masami; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Himes, Blanca E.; Litonjua, Augusto A.; Tantisira, Kelan G.; Weiss, Scott T.; Kamatani, Naoyuki; Nakamura, Yusuke; Tamari, Mayumi.

In: Nature Genetics, Vol. 43, No. 9, 01.09.2011, p. 893-896.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

AU - Hirota, Tomomitsu

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Tsunoda, Tatsuhiko

AU - Tomita, Kaori

AU - Doi, Satoru

AU - Fujita, Kimie

AU - Miyatake, Akihiko

AU - Enomoto, Tadao

AU - Miyagawa, Takehiko

AU - Adachi, Mitsuru

AU - Tanaka, Hiroshi

AU - Niimi, Akio

AU - Matsumoto, Hisako

AU - Ito, Isao

AU - Masuko, Hironori

AU - Sakamoto, Tohru

AU - Hizawa, Nobuyuki

AU - Taniguchi, Masami

AU - Lima, John J.

AU - Irvin, Charles G.

AU - Peters, Stephen P.

AU - Himes, Blanca E.

AU - Litonjua, Augusto A.

AU - Tantisira, Kelan G.

AU - Weiss, Scott T.

AU - Kamatani, Naoyuki

AU - Nakamura, Yusuke

AU - Tamari, Mayumi

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87×10 -12), a locus on chromosome 10p14 (P = 1.79 ×-10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 ×10 -13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07× 10 -23), which is close to rs2070600, a SNP previously reported for association with FEV 1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.

AB - Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87×10 -12), a locus on chromosome 10p14 (P = 1.79 ×-10-15) and a gene-rich region on chromosome 12q13 (P = 2.33 ×10 -13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07× 10 -23), which is close to rs2070600, a SNP previously reported for association with FEV 1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=80052273202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052273202&partnerID=8YFLogxK

U2 - 10.1038/ng.887

DO - 10.1038/ng.887

M3 - Article

C2 - 21804548

AN - SCOPUS:80052273202

VL - 43

SP - 893

EP - 896

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -